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Molecular mechanism of initiation of DNA replication

Research Project

Project/Area Number 60304097
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 分子遺伝学・分子生理学
Research InstitutionNagoya University

Principal Investigator

OKAZAKI Tuneko  Nagoya University, 理学部, 教授 (10022584)

Co-Investigator(Kenkyū-buntansha) ARIGA Hiroshi  University of Tokyo, 医科学研究所, 助手 (20143505)
SENO Takeshi  Saitama Cancer Center, 研究所, 部長 (30076989)
YAMAGUCHI Kazuo  Kanazawa University, 遺伝子実験施設, 助教授 (00019879)
HIRAGA Sota  Kumamoto University, 医学部, 教授 (40027321)
YOSHIKAWA Hirose  Osaka University, 医学部, 教授 (70019876)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 1987: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1985: ¥8,700,000 (Direct Cost: ¥8,700,000)
Keywordsinitiator protein / origin sequence / RAN-DNA transition site / autoregulation / transcription / ARS / 複製開始機構 / Rep蛋白 / ori DNA
Research Abstract

Mechanism of initiation of DNA replication of various genomes has been studid co-operatively by many investigators. Regulation of the initiation of plasmid DNA replication has been analyzed in emphasis on the interaction between initiator proteins and target DNA sequence at the origin region of each plasmid. Plasmids R6K, F, pSC101, Co1E1, Co1E2, Co1E3, dv and E. coli oriC plasmid have been investigated. Transcription regulation in E. coli oriC has been analyzed in vivo and in vitro. Gene organization of B. subtilis replication origin has been analyzed and high similarities to E. coli genome have been revealed. Priming sites (transition sites from primer RNA to DNA) at replication origins of various genomes have been determined. fermination loci of DNA replication of R6K and E. coli genome have been cloned. Structure and function of the F plasmid genes essential for partitioning has been clarified. Autonomously replicating sequences have been cloned from mammalian cells and possible function of c-myc product in promotion of initiation of replication has been shown. The structure of thymidylate synthase gene has been determined and transcription regulation has been studied. Reverse transcriptase encoded by cauliflower mosaic virus (CaMV) genome has been investigated and involvement of RNA as an intermediate of CaMV DNA replication has been shown.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (77 results)

All Other

All Publications (77 results)

  • [Publications] Sugumoto, K.et al.: Proc. Natl. Acad. Sci. USA. 84. 3977-3981 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Sugimoto, K. et al.: Mol. Gen. Genet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nozaki, N.: J. Biol. Chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoda, K. etal.: Nucleic Acids Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ariga, H. et al.: Mol. cell. Biol.7. 1-6 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Itani, T. et al.: Gene. 56. 267-276 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iguchi-Ariga, S. et al.: EMBO J.6. 2365-2371 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iguchi-Ariga, S. et al.: Life Science Advances. 6. 75-84 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iguchi-Ariga, S. et al.: Nucleic Acids res.15. 4889-4899 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Unuzuka, M.et al.: FEBS Letters. 228. 7-11 (1978)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Horii, T. et al.: Mol. Gen. Genet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Murakami, Y. et al.: J.Bacteriol.169. 1724-1730 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] ohmori, H. et al.: J. Mol. Biol.198. 223-234 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kusukawa,N. et al.: Mol. Gen. Genet.208. 365-372 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akiyama, M.et al.: Mol. Gen. Genent.206. 9-16 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Horiuch, T. et al.: Mol. Gen. Gent.206. 356-357 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Horiuchi, T. et al.: Mol Gen. Genet.210. 394-398 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kaneda,S. et al.: Nucleic Acids Res.15. 1259-1270 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yagura, T. et al.: Biochemistry. 26. 7749-7754 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoshida, A. et al.: J.Biol.Chem.17. 8235-8241 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ariga,H.: Nucleic Acids Res.14. 9457-9470 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takatsuju, H. et al.: Nature. 319. 240-243 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Itoh, T.: Adv. Biophys.21. 105-113 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inuzuka, M.: Ann.Rep.,Inst.virus Res.Kyoto Univ.29. 35-36 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ohki, M. et al.: J.Biol. Chem.261. 1778-1781 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Naito, S. et al.: J. Bacteriol.166. 143-147 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kozu, T. et. al.: Eru.j. Biochem.157. 251-259 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yagura, T. et al.: Biochim. Biophys. Acta. 873. 1-11 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ayusawa, D. et al.: J. Mol. Biol.190. 559-567 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ayusawa, D. et al.: Mol. Cell. Biol.6. 3463-3469 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiraga, S. et al.: J. Bacteriol.166. 100-104 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Moru, H. et al.: J. Mol. Biol.192. 1-15 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takano, K. et al.: Mol. Gen. Genet.205. 9-13 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tokino, T. et al.: proc. Natl. Acad. Sci. USA. 83. 4109-4113 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Muraiso,K.et al.: Mol. Gen. genet.206. 519-521 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kouhara, H. et al.: Mol. Gen. Genet.208. 428-435 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hase, T. etal.: J. Gen. Appl. Microbiol.32. 405- (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ogasawara, N. et al.: Gene. 45. 227-231 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ogasawara, N. et al.: Nucleic Acids Res.14. 9989-9999 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ariga, H. et al.: Mol. Cell. Biol.5. 563-568 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hirochika, H. et al.: Mol. cell. Biol.5. 563-568 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hirochika, H. et al.: EMBO J.4. 1673-1680 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inuzuka, M.: FEBS Letters. 181. 236-240 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Jaffe, A. et al.: J. Bacteriol.163. 841-849 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hayakawa, Y. et al: J.Bacteriol.163. 349-354 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Matui, M. et al.: J.Mol. Biol.184. 529-533 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yamaguchi, K. et al.: Mol. Gen. Genet.200. 362-367 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Moriya, S. et al.: Nucleic Acids Res.13. 2251-2265 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ogasawara,N. et al.: Nucleic Acids Res.13. 2267-2279 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inuzuka, M. et al.: EMBO J.4. 2301-2307 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasuda, H. et al.: Nucleic Cids Res.13. 4953-4969 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kohara, Y. et al.: Nucleic Acids Res.13. 6874-6866 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kitani, t. et al.: J.Mol. Biol.184. 45-52 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Murakami, Y. et al.: J. Bacteriol.162. 830-832 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tanaka, M.et al.: Mol. Gen. Genet.200. 21-26 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 堀内 嵩: "新基礎生化学実験法 第1巻 生物材料の取り扱い" 24 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 山口和男: "遺伝子工学実験講座" 日本アイソトープ協会, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 山口和男: "免疫実験操作法" 南江堂,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Moriya, S.; Fukuoka, T.; Ogasawara, N.; and Yoshikawa,Y.: "Genetics and biotechnology of Bacilli Vol. II" Academic Press,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Sugimoto, K. et al.: "Relative roles of T7 RNA polymerase and gene 4 primase for the initiation of T7 phage DNA replication in vivo." Proc. Natl. Acad. Sci. USA. 84. 3977-3981 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Sugimoto, K. et al.: "Change in priming sites for discontinuous DNA synthisis between the monomeric and concatemeric stages of phage T7 replication" Mol. Gen. Genet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nazaki, N. at al.: "In vitro transcription of the origin region of replication of the Escherichiacoli chromosome." J. Biol. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoda, K. et al.: "RNA-primed initiation sites of DNA replication in the origin region of bacteriophage lambda genome." Nucleic Ac ids Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ariga, H. et al.: "Autonomous replicating sequences from mouse cells which can replicate in mousecells in vivo and in vitro." Mol. Cell. Biol.7. 1-6 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Moriya, S. et al.: Genetics and Biotechnology of Bacilli. Vol. II. Academic Press,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kenji Sugimoto: Proc.Natl.Acad.Sci.USA. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tateo Itoh: Advances of Biophysics. 21. 105-113 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Naotaka Ogasawara: Nucleic Acids Res.14. 9989-9999 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Naotaka Ogasawara: Gene. 45. 227-231 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Sumiko Kaneda: Nucleic Acids Res.

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Yagura: Biochim.Biophys.Acta. 870. 1-11 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Kozu: Eur.J.Biochem.157. 251-259 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hiroyosi Ariga: Mol.Cell.Biol.7. 1-6 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Sanae Iguchi-Ariga: Cell. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Itani: Gene.

    • Related Report
      1986 Annual Research Report
  • [Publications] Sanae Iguchi-Ariga: EMBO J.

    • Related Report
      1986 Annual Research Report
  • [Publications] Yota Murakami: J.Bacteriol.(1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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