| Co-Investigator(Kenkyū-buntansha) |
NOZOE Shogeo Tohoku University.Professor, 薬学部, 教授 (50013305)
KANEKO Chikara Tohoku University.Professor, 薬学部, 教授 (40013833)
FUKUMOTO Keiichiro Tohoku University.Professor, 薬学部, 教授 (50004586)
YAMANAKA Hiroshi Tohoku University.Professor, 薬学部, 教授 (40004551)
NAMBARA Toshio Tohoku University.Professor, 薬学部, 教授 (30004534)
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| Budget Amount *help |
¥28,500,000 (Direct Cost: ¥28,500,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1985: ¥21,000,000 (Direct Cost: ¥21,000,000)
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| Keywords | prostanoids / catechol estrogen glucronides / 1,2,4-triazoles / aconitum alkaloids / アコニチンアルカロイド / βーラクタム / 炭素Cーヌクレオシド / 担子菌 / 電気化学検出 / 排卵促進 / アチシン / キラル合成 / 血小板凝集阻止 / ディールス / アルダー反応 / 1,2,4-トリアジン / 血小板凝集阻止作用 / 炭素環C-ヌクレオチド / チオノラクトン / カテヨールエストロゲン / グルクロニル化 / 血小板凝集抑制 / トリアジン / イミニウム・エン反応 / 1,3ージオキシン / 抗菌性物質 / ステロイドアルカロイド / プロトン化 / 電気化学検出高速液体クロマトグラフィー / Wittig反応 / 分子内反応 / 2+2光環化反応 / β-ラクタム / 抗真菌性物質 / プロスタサイクリン / 抱合型エストロゲン / 直接イムノアッセイ / 血小板抑制 / 光反応 / 変形アミノ酸 / 有毒担子菌 |
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| Research Abstract |
In order to discover new promising drugs, investigation on naturally occurrng bioactive minute compounds have been inbestigated during the period from 1985 to 1988 from the chemical and pharmaceutical points of view. The investigation was carried out by co-operation of six researchers of Pharmaceutical Institute, Tohoku University, led by Dr. Seiichi Takano, Professor. The investigation consists of six subjects, namely, "Chiral Synthesis of Prostacyclines and the Related Compounds" (Dr. S. Takano, Professor), "Analytical Studies of Catechol Estrogens" (Dr. T. Nambara, Professor), "Synthesis and Pharmacology of the 1,2,4-Triazine Derivatives" (Dr. H. Yamanaka, Professor), "Synthesis of the Aconitum Alkaloids and the Related Compounds" (Dr. K. Fukumoto, Professor), "Syntheses of -Lactams and Carbocyclic C-Nucleoside" (Dr. C. Kaneko, Professor), and "Constituents of Basidiomycetes" (Dr. S. Nozoe, Professor). During the investigation period, the followings have been established, (a) new efficient methods for the separation and the characterization of catechol estrogen metabolites using highperformance liquid chromatography and radioimmuno-assay techniques, (b) a highly enantioselective synthesis of the prostanoid intermediates, (c) preparation and discovery of new bio-active 1,2,4-triazine derivatives, (d) establishment of the intramolecular double Michael addition and imminium-ene reaction and their application for the total sythesis of atisine, (e) a new syntesis of -lactam derivatives by both the photochemical and thermochemical methods and a new synthesis of the carbocyclic C-nucleaside derivatives, (f) isolation and characterization of new antimicrobial and ovulatory substances from the Basidiomycetes and the related fungi.
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