| Project/Area Number |
60440024
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
神経解剖学
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SANO Yutaka Kyoto Prefectural University of Medicine, 教授 (00079683)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Shuichi Kyoto Prefectural University of Medicine, 助手 (60150570)
YAMADA Hisao Kyoto Prefectural University of Medicine, 助手 (00142373)
KAWATA Mitsuhiro Kyoto Prefectural University of Medicine, 助教授 (60112512)
MATSUURA Tadao Meiji Colloege of Oriental Medicine, 教授 (30079686)
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| Project Period (FY) |
1985 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥25,700,000 (Direct Cost: ¥25,700,000)
Fiscal Year 1987: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1986: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1985: ¥19,000,000 (Direct Cost: ¥19,000,000)
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| Keywords | Serotonin / Immunohistochemistry / CNS / Axonal Network / 網状軸索 / セロトニンニューロン / 層的分布 / 可塑性 / 脳移植 / 中枢神経 / アミンニューロン |
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| Research Abstract |
Serotonin antiserum was obtained by immunization of rabbits with serotonin coupled with bovine thyroglobulin by the mannich reaction. Using the immunohistochemical technique, maps of the distribution of serotonin neurons were made for the CNS of various mammals and other vertebrate classes. The total numbers of serotonin neurons in the brain were about 25,000 in mice, 50,000 in rat, and 135,000 in monkey. Most of these neurons in the brainstem occupy large parts of the raphe nuclei. The axonal processes of serotonin neurons continue to long branched fibers that are complicated and widely spread. All fibers contain many small, spherical varicosities. Except for thick myelinated tracts, serotonin fibers are distributed in all areas of the CNS. In the visual cortex of Macaca fuscata, the overall density of varicose fibers is about 770,000/mm^3 and the concentration of immunoreactive varicosities (ca 1,400,000/mm^3) is highest in the layer IVc. Serotonin fivers are to be found in the ventricular lumen and the subarachnoid space.
Processes of serotonin neurons form a wide-spread network by the repetition of ramifications and reunions. Such three-dimensional networks are formed in almost all regions of gray matter. The serotonin neuron system does not correspond to a certain nervous circuit to connect centers for special functions. These neurons are related to other neurons through en passant type synapses, and may exert their effect on those neurons en masse.
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