| Project/Area Number |
60440055
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Niigata University |
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Principal Investigator |
SHIBATA Akira Niigata University School of Medicine, 医学部, 教授 (10004772)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masuhiro Niigata University School of Medicine, 医学部, 助手 (90179531)
KOIKE Tadashi Niigata University School of Medicine, 医学部附属病院, 助手 (30170161)
TAKAHASHI Hoyu Niigata University School of Medicine, 医学部附属病院, 助手 (70163285)
MORIYAMA Yoshiaki Niigata University School of Medicine, 医学部附属病院, 助教授 (00018706)
HATTORI Akira Niigata University School of Medicine, 医学部, 助教授 (10018731)
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| Project Period (FY) |
1985 – 1988
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1985: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | Megakaryoblast / Platelet peroxidase / Platelet Glycoprotein / Megakaryoblastic Leukemia / Thrombocythemia / 血小板ペルオキシダーゼ / 骨髄線維症 / 血小板ペルオキシターゼ / TAM / KU812 / 巨核球性白血病 / 血小板ぺルオキシダーゼ / 血小板糖蛋白【II】b / 【III】a / 白血病表面抗原 / 白血病 / PPO反応 / 血小板GP【II】b / PDGF / インターフェロン / 本態性血小板血症 |
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| Research Abstract |
Megakaryoblastic leukemia is a newly defined type of leukemia. Platelet peroxidase(PPO) has been thought to be specific to megakaryocytic lineage and has been used as a marker for identification of megakaryoblasts. Recently, however, it become clear that monoclonal anti-platelet antibodies, especially CD41, are more conventional for the identification of megakaryoblasts. (1) We found that PPO activity appears earlier than platelet GPIIb/IIIa in the maturation of megakaryocytic cells. (2) We found that PPO-like activity can be detected in erythroblasts. It become clear that PPO- like activity can be detected immature erythroblasts at the level of CFU-E. (3) We found that immature megakaryoblasts express CD33(panmyeloid antigen). (4) We pointed out that megakaryoblastic leukemia, especially presenting as acute myelofibrosis, is a multipotential stem cell disorder.
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