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Study on Megakaryocytic Leukemia

Research Project

Project/Area Number 60440055
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionNiigata University

Principal Investigator

SHIBATA Akira  Niigata University School of Medicine, 医学部, 教授 (10004772)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Masuhiro  Niigata University School of Medicine, 医学部, 助手 (90179531)
KOIKE Tadashi  Niigata University School of Medicine, 医学部附属病院, 助手 (30170161)
TAKAHASHI Hoyu  Niigata University School of Medicine, 医学部附属病院, 助手 (70163285)
MORIYAMA Yoshiaki  Niigata University School of Medicine, 医学部附属病院, 助教授 (00018706)
HATTORI Akira  Niigata University School of Medicine, 医学部, 助教授 (10018731)
Project Period (FY) 1985 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1985: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsMegakaryoblast / Platelet peroxidase / Platelet Glycoprotein / Megakaryoblastic Leukemia / Thrombocythemia / 血小板ペルオキシダーゼ / 骨髄線維症 / 血小板ペルオキシターゼ / TAM / KU812 / 巨核球性白血病 / 血小板ぺルオキシダーゼ / 血小板糖蛋白【II】b / 【III】a / 白血病表面抗原 / 白血病 / PPO反応 / 血小板GP【II】b / PDGF / インターフェロン / 本態性血小板血症
Research Abstract

Megakaryoblastic leukemia is a newly defined type of leukemia. Platelet peroxidase(PPO) has been thought to be specific to megakaryocytic lineage and has been used as a marker for identification of megakaryoblasts. Recently, however, it become clear that monoclonal anti-platelet antibodies, especially CD41, are more conventional for the identification of megakaryoblasts. (1) We found that PPO activity appears earlier than platelet GPIIb/IIIa in the maturation of megakaryocytic cells. (2) We found that PPO-like activity can be detected in erythroblasts. It become clear that PPO- like activity can be detected immature erythroblasts at the level of CFU-E. (3) We found that immature megakaryoblasts express CD33(panmyeloid antigen). (4) We pointed out that megakaryoblastic leukemia, especially presenting as acute myelofibrosis, is a multipotential stem cell disorder.

Report

(5 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • 1985 Annual Research Report

Research Products

(22 results)

All Other

All Publications (22 results)

  • [Publications] Tadashi Koike: "Megakaryoblastic Leukemia:The Characterization and Identification of Megakaryoblasts" BLOOD. 64. 683-692 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akira Shibata: "Recent Advances in the Study of Megakaryoblastic Leukemia" Acta Haematologica Japohica. 1985. 48 (67-76)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Perinuclear Peroxidatic Activity in Erythroblasts" British Journal of Haematology. 64. 621-623 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Cell Surface Phenotyping of Megakaryoblasts" BLOOD. 69. 957-960 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Early Erythroblastic Leukemia Presenting as de novo Acute Leukemia" Leukemia and Lymphoma. in Press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 柴田昭,高久史麿: "白血病の新しい診断技術" 医歯薬出版株式会社, 183 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Megakaryoblastic Leukemia: The Characterization and Identification of Megakaryoblast" BLOOD. 64. 683-692 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akira Shibata: "Recent Advances in the Study of Megakaryoblastic Leukemia" Acta Hematologica Japonica. 48. 67-76 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Perinuclear Peroxidatic Activity in Erythroblasts" British Journal Of Haematology. 64. 621-623 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Cell Surface Phenotyping of Megakaryoblasts" BLOOD. 69. 957-960 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tadashi Koike: "Early Erythroblastic Leukemia Presenting as de novo Acute Leukemia" Leukemia and Lymphoma. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Koike,T.;Shibata,A.;et al.: in preparation.

    • Related Report
      1988 Annual Research Report
  • [Publications] Shibata,A.;et al.: Blut.

    • Related Report
      1988 Annual Research Report
  • [Publications] Tadashi Koike: Blood. 69. 957-961 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Akira Shibata: Keio Journal of Medicine. 36. 62-66 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tadashi Koike: Acta Hematologica Japonica. 50. 1519-1530 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tadashi Koike: Exp Hematol. 15. 602 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tadashi Koike et al: Blood. 69. 957-961 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Andrews RG;Masuhiro Takahashi et al: Blood. 68. 1030-1035 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tadashi Koike et al: British Journal of Haematology. 64. 621-624 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tadashi Koike et al: Experimental Haematology. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] ACTA HAEMATOLOGICA JAPONICA. 48巻-7号. (1985)

    • Related Report
      1985 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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