| Project/Area Number |
60440059
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
WATANABE Hiroki Kyoto Prefectural University of Medicine, Dept. of Urology. Professor, 医学部(泌尿器科学), 教授 (10004839)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITO Akira Kyoto Prefectural University of Medicine, Dept. of Urology. Assistant, 医学部(泌尿器科学), 助手
NAKAGAWA Yuji Kyoto Prefectural University of Medicine, Dept. of Urology. Assistant, 医学部(泌尿器科学), 助手 (10198046)
UCHIDA Mutsmi Kyoto Prefectural University of Medicine, Dept. of Urology. Assistant, 医学部(泌尿器科学), 助手 (70168706)
TAKAHASHI Toshio Kyoto Prefectural University of Medicine, lst. Dept. of Surgery. Professor, 医学部(外科学), 教授 (50079828)
中尾 昌宏 京都府立医科大学, 医学部(泌尿器科学), 助手 (00188880)
斉藤 雅人 京都府立医科大学, 医学部(泌尿器科学), 講師 (70106417)
板倉 康啓 京都府立医科大学, 医学部(泌尿器科学), 助手 (50151452)
金子 宏 京都府立医科大学, 医学部(泌尿器科学), 助手 (10152802)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥24,200,000 (Direct Cost: ¥24,200,000)
Fiscal Year 1987: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1986: ¥9,200,000 (Direct Cost: ¥9,200,000)
Fiscal Year 1985: ¥9,800,000 (Direct Cost: ¥9,800,000)
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| Keywords | Pin-hammer / Microexplosion / Renal calculus / Ureteral calculus / Biliary calculus / 破砕システム / 尿路結石 / 腎 / 尿管 / 尿路結石衝撃応答解析 / 損傷管腔の修復過程 |
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| Research Abstract |
There are two kinds of action in explosion; dynamic action due to the energy of shock wave and static action due to the energy of gas generated in detonation. An exploseve catheter mainly using dynamic action was developed. Up to date microexplosion cystolithotripsy using this catheter was performed in 131 cases with a success rate of 100 %. At present microexplosion lithotripsy is the best method for bladder calculi removal. However, the explosive catheter could not be applied to the destruction of ureteral, renal and biliary calculi, because of harmful gas generation. For the settlement of that reason, we newly developed two types of lithotriptor; a pin-hammer and capsule type. A detonation power of these lithotriptors was exanimed. As the result, a pin-hammer lithotriptor was suitable. Three mg trinitroresorcinate is used for explosive. The explosives, an ignition system and a pin-hammer are loaded inside a stainless steel cylindrical chamber 2.6 mm in diameter and 31 mm length. By blasting, the pin-hammer, with a diameter of 1.3 mm, is pushed out from the chamber at a initial velocity of 120 m/sec by generated gas and is controlled not to overrun at a distance of 5 mm from the tip of the chamber. The compressive strength of ureteral and biliary calculi was below 65 kg/cm^2 and belonged to the low strength group. These calculi within 13 mm in diameter were destructed using this lithotriptor. The tensile strength of ureter was alomost equal to gall bladder and bile duct. These materials were suitable in microexplosion. Expected ureteral injury by the pin-hammer was cured within 3days. The application of pin-hammer microexplosion was in 48 patients with ureteral and renal calculi, with a success rate of 65 %. In future we will make efforts to improve a success rate and to destruct biliary calculi.
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