| Project/Area Number |
60440065
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | JIKEI university school of medicine |
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Principal Investigator |
ARAI Tatsuta JIKEI University School of Medicine, 医学部・心臓外科, 教授 (60056471)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Yoshihiko JIKEI Univercity School of Medicine, 医学部・心臓外科, 助手 (20174344)
MASHIKO Keno JIKEI Univercity School of Medicine, 医学部・心臓外科, 助手 (50138799)
SASAKI Tatsuumi JIKEI Univercity School of Medicine, 医学部・心臓外科, 助手 (20138754)
SUZUKI Shigeru JIKEI Univercity School of Medicine, 医学部・心臓外科, 講師 (50130175)
HORIKOSHI Shigeki JIKEI Univercity School of Medicine, 医学部・心臓外科, 助教授 (90056987)
小机 敏昭 東京慈恵会医科大学, 医学部, 講師 (10130163)
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| Project Period (FY) |
1985 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1986: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1985: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | Ultrasound Myocardial Stimulation / Ventricular function / Cardioplegia / 再灌流 / 再潅流 |
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| Research Abstract |
Powerful ultrasound is used for therpeutic purposes in various fields of medicine, such as urology, neurosurgery and so on. In the cardiovascular field,however, it has been employed exclusively for diagnostic purposes. We investigated the effect of ultrasound stimulation on ventricular function in isolatid perfused rat heart and in the right herat bypass model of dog.
Results 1)The ultrasound stimulatin might have a protective effect against an ishemic insult upon myocardial cell during hypothermic cardioplegic arrest. 2)The ultrasound stimulation does not oppose the action of Verapamil, nor produce Ca-overload,exerting benefical effect on the recovery of cardiac function from fypothermic cardiac arrest. 3)The ATP depletion during cardiac arrest was attenuated by the ultrasound stimulation and exogenous ATP resulted in high recovery of ventricular function during reperfusion. 4)We have investigated the usufulness of the ultrasound myocardial stimulator using mongel dog for the purpose of clinical aplication. Satisfactory results were obtained when we used the refined model to make the stimulator more easily feasible in clinical practice. The data suggest the prospective effect on the ishemic heart and promise for clinical application.
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