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The application and evaluation of a newly developed laser to photodynamic cancer therapy

Research Project

Project/Area Number 60440075
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKanazawa University

Principal Investigator

HISAZUMI Haruo  Kanazawa University, School of Medicine, Professor, 医学部, 教授 (70019537)

Co-Investigator(Kenkyū-buntansha) UCHIBAYASHI Tadao  Kanazawa University, School fo Medicine, Assistant Doctor, 医学部付属病院, 助手 (90151894)
NAITO Katsusuke  Kanazawa University, School fo Medicine, Lecturer, 医学部付属病院, 講師 (60115251)
MISAKI Toshimitsu  Kanazawa University, School of Medicine, Lecturer, 医学部付属病院, 講師 (50020003)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥20,300,000 (Direct Cost: ¥20,300,000)
Fiscal Year 1987: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1986: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1985: ¥15,000,000 (Direct Cost: ¥15,000,000)
KeywordsPhotodynamic therapy / Gold vapor laser / Hyperthermia / Photobleaching / Hematoporphyrin derivative / Photosensitizers / 金蒸気レーザー / 光力学的治療 / 膀胱腫瘍 / 温熱療法 / 膀胱癌モノクローナル抗体 / フタロシアニン / 癌光化学治療 / 簡便な膀胱壁全照射装置 / HPD組織内分布 / HPD / 分光学的特性 / アルゴン色素レーザー
Research Abstract

1. A gold vapor laser (GVL) exerted spectroscopically photobleaching to HpD and other absorbers in tissue which resulted in an increase in tissue penetration and contributed intratumoral 43゜c hyperthermia. A combination of HpD-PDT and the hyperthermia significantly enhanced tumor destruction and cut down irradation time. 2. ALCL-phthalocyanine (PC) and HpD polymer (MW:12000) showed a greater photodynamic cell killing as compared with HpD using 630nm red light. A HPLC study revealed a higher tumor accumulation of PC in tumor-bearing animals. PC was thought to be promising drug in the future. 3. There was no difference of in vitro cellular uptake between HpD and 3 HpD-conjugated monoclonal antibodies obtained from T24 cells. 4. In vitro HpD-cellular uptake was low in the order: HpD-adriamycin(ADM)(a), ADM-HpD(b) and ADM+HpD(c). The cell killing of ADM received no change in (b) and (c), but a decrease in (a). The effect of laser irradiation on these combinations should be studied. 5. The … More focusing of GVL beam into a 600um optic fiber was significantly increased when an unstable resonator oprics and 50 < ph>mm bilateral convex lens, FL86mm, were used, the transmission rate being approx.75%. 6. Morphological studies of HpD-photodynamic cell killing revealed a marked degradation of mitochondria and cell membrane as an initial change and then followed by nuclear damage. These changes were supported by the data in biochemical studies and in accordance with intracellular HpD distribution. 7. Focal HpD-PDT with less than 100J/sqcm acheved 100 and 58% CR for 15 and 33 bladder tumors less than 2cm in size using the GVL and an argon dye laser, respectively. 8. A simple laser light scattering device using 3% Intralipos was designed for whole bladder wall HpD-PDT and applied to rabbit bladders bearing Vx2 carcinomas and multiple superficial bladder tumors. The device proved to be clinically useful and approx. 20J/sqcm may be suitable. 9. Endoscopic HpD fluorescence cancer imaging system consists of UV light, photoncounting device and R60 and DIF filters was devised and tested for the rabbit bladder tumors. The results were encouraging for clinical application. Less

Report

(3 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • 1985 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 久住 治男: 日本ハイパーサーミア誌. 2. 142-155 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 打林 忠雄: 日本レーザー医学会誌. 7. 135-136 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三崎 俊光: 日泌尿会誌. 78. 572-578 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 久住 治男: 日本ME学会BME. 1. 536-540 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 久住 治男: 日本レーザー医学会誌. 8. 11-14 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Amano,Toshiyasu: J. Urol.139. 392-395 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 久住 治男: "膀胱癌のレーザー療法,図説臨柱『癌』シリーズ" メジカルビュー社, 8 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 久住 治男: "光線力学的レーザー,膀胱癌,レーザー腫瘍治療マニュアル" サイエンスフォーラム, 8 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hisazumi, Haruo: "Experimental studies on the usefulness of a gold vapor laser in photodynamic cancer therapy" Jpn. J. Hyperthermic Oncology. 2. 142-155 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Uchibayashi, Tadao: "Whole bladder wall photodynamic therapy using a newly designed light-scattering device fr superficial multicentric bladder tumors" J. Jpn. Society for Laser Medicine. 7. 135-136 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Misaki, Toshimitsu: "Distribution and phototoxicity of hematoporphyrin deruvatuve in experimentally induced rat bladder tumors" Jpn. J. Urol.78. 572-578 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Misaki, Toshimitsu: "A study of tissue distribution of hematoporpyrin derivative in cystectomy specimens" Jpn. J. Urol.78. 1496-1502 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hisazumi, Haruo: "HpD photodynamic therapy using a gold vapor laser with reference to the usefulness of the induced hyperthermia" J. Jpn. Society for Laser Medicine. 7. 49-50 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hisazumi, Haruo: Progress in Cencer Clinics, Bladder Cancer: Laser Therapy. Medical View Co., 42-49 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 久住治男 他: 日本ハイパーサーミヤ誌. 2. 142-155 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 打林忠雄 他: 日本レーザー医学会誌. 7. 135-136 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 三崎俊光 他: 泌尿器科紀要. 32. 1941-1948 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 久住治男: 治療学. 17. 191-194 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 中嶋和喜 他: 日本ハイパーサーミヤ誌. 2. 165-169 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Haruo Hisazumi et al.: Lasers in Medical Science.

    • Related Report
      1986 Annual Research Report
  • [Publications] 久住治男 他: "レーザー腫瘍治療マニュアル(膀胱癌.光力学的レーザー)" 早田義博 (株)サイエンスフォーラム, 225 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 久住治男: "泌尿器科Q & A(膀胱腫瘍のレーザー治療)" 町田豊平 金原出版株式会社, 277 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 日本レーザー医学会誌. 6-1. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Photomedicine and Photobiology. 7-2. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] 癌の臨床. 31-6. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] 日本レーザー医学会誌. 6-3. (1986)

    • Related Report
      1985 Annual Research Report
  • [Publications] 日本レーザー医学会誌. 6-3. (1986)

    • Related Report
      1985 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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