| Project/Area Number |
60440092
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
小児・社会系歯学
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKATA Minoru Department of Pediatric Dentistry,Kyushu University Faculty of Dentistry.Profess, 歯学部, 教授 (40014013)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Toshihide Department of Pediatric Dentistry,Kyushu University Faculty of Dentistry.Instuct, 歯学部付属病院, 助手 (60199883)
NONAKA Kazuaki Department of Pediatric Dentistry,Kyushu University Faculty of Dentistry.Instuct, 歯学部, 助手 (90128067)
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| Project Period (FY) |
1985 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥25,700,000 (Direct Cost: ¥25,700,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1985: ¥23,500,000 (Direct Cost: ¥23,500,000)
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| Keywords | Oral-Facial Genetics / Growth / Genetics / 母体効果 / 歯・顎・顔面 / 受精卵移植 / 歯 / 顎 / 顔面 |
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| Research Abstract |
The continuous variables, such as tooth size and jaw size, are characters that can be measured against a continuous scale. Such continuous variables usually have a multifactorial basis ; that is, several genes and environmental influences, each with a relatively small effect, contribute to an individual position on the continuous scale.
Multivactorial inheritance, also known as polygenis or quantitative inheritance, is not easy to analyze, but a number of method have been developed to demonstrate it. The simplest of these is the method of resemblance between relatives ; that is, the demonstration that the more closely related two individuals are, the more closely they resemble each other in the trait in question.
Based on the genetic study using the experimental animals it was indicated that there is the antagonistic "behavior" between the genetic and maternal factor through all experimental periods for each segment of the craniofacial complex. The maternal effect disappears earlier in females than males, and appears related to the fact that females attain adult size earlier than males. In the early stages of dento-facial growth, the main source of the variation is attributed to variance on the maternal effect, and later as the maternal effect decreases or disappears, the genetic effect becomes a more significant factor in determining the dento-facial size.
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