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Surface Chemical Study on Polymer Latex for Immuno-diagonosis

Research Project

Project/Area Number 60470081
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 工業物理化学
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

SUZAWA TOSHIRO  HIROSHIMA UNIVERSITY, FACULTY OF ENGINEERING, PROFESSOR, 工学部, 教授 (20034291)

Co-Investigator(Kenkyū-buntansha) SHIRAHAMA HIROYUKI  HIROSHIMA UNIVERSITY, 工学部, 助手 (60127660)
TAMAI HISASHI  HIROSHIMA UNIVERSITY, 工学部, 助手 (40106802)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsImmuno-diagnosis / Dispersion-stability / 表面特性 / 凝集性 / 分散安定性
Research Abstract

Copolymer latices having functional and hydrophilic groups on their surfaces, i. e., styrene/2-hydroxyethyl methacrylate (HEMA)/acrylic acid (AA) copolymer [P(St/HEMA/AA)] and styrene/acrylamide (AAm)/AA copolymer [P(St/AAm/AA)] latices expected for immuno-diagnosis were prepared without emulsifier. Electron micrographs of these latices revealed that the latex particles were highly monodisperse. Viscosity and <zeta> -potential measurements of latex dispersions showed that hydrogel layers derived from poly-HEMA ( or poly-AAm) and poly-AA existed on the surfaces of these latices.
The stability of latex dispersions increased with increasing the quantity of HEMA or AAm used in the copolymerization, and changed by pH. Further, the coagulation rate of latex dispersions increased with an increase of temperature. This is probably because the steric repulsion between latex particles decreases with increasing temperature.
Furthermore, the coagulation rate of BSA-covered latex particles increased in the lower concentration region of NaCl, but decreased in the higher NaCl concentration region. Nevertheless in general, it was found that the stability of latex dispersions was enhanced by covering with BSA molecule.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] H.Tamai;T.Murakami;T.Suzawa: J.Applied Polymer Sci.30. 3857-3866 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 玉井久司,須澤利郎: 油化学. 34. 997-1007 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H.Tamai;Y.Ishii;Y.Kodera;T.Suzawa: J.Colloid Interface Sci.114. 267-269 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H.Tamai;H.Shirahama;T.Ekimoto;T.Suzawa: 油化学. 35. 737-741 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H.Tamai;A.Fujii;T.Suzawa: J.Colloid Interface Sci.印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] K.Kawasaki;H.Tamai;T.Suzawa: Textile Res.J.56. 598-603 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 須澤利郎著,筏義人編: "高分子表面の基礎と応用、上巻" 化学同人, 24 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H. Tamai, T. Murakami, T. Suzawa: "Surface Characterization of Styrene/Acrylamide Copolymer Latex Particles" J. Applied Polymer Sci.30. 3857-3866 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H. Tamai, Y. Ishii, Y. Kodera, T. Suzawa: "Deposition of Polystyrene Latex Coated with Poly(vinyl alcohol) on Polyacrylonitrile Fiber" J. Colloid Interface Sci.114. 267-269 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H. Tamai, H. Shirahama, T. Ekimoto, T. Suzawa: "Anomalous Deposition of Styrene/2-Hydroxyethyl Methacrylate Copolymer Latex on Fibers" Yukagaku (J. Japan Oil Chemists' Soc.). 35. 737-741 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H. Tamai, A. Fujii, T. Suzawa: "Some Colloidal Considerations on the Surface Characteristics of various Emulsifier-free Polymer Latices" J. Colloid Interface Sci.in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] K. Kawasaki, H. Tamai, T. Suzawa: "Effect of Sodium Dodecyl Sulfate on Deposition of Polymer Latices onto Polyester and Cotton Fibers" Textile Res. J.56. 598-603 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] TOSHIRO SUZAWA: KAGAKU DOJIN. KOBUNSHI-HYOMEN NO KISO TO OYO (POLYMER SURFACE-BASIS AND APPLICATION) (Ed. Y. IKADA), 247-270 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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