| Project/Area Number |
60470112
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子合成
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMADA Kimiho Faculty of Engineering, Kumamoto University, Professor, 工学部, 教授 (40040349)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Noriko Faculty of Engineering, Kumamoto University, Assistant, 工学部, 助手 (80180496)
IWATA Hiroko Faculty of Engineering, Kumamoto University, Assistant, 工学部, 助手 (00292566)
KOIDE Yoshifumi Faculty of Engineering, Kumamoto University, Assistant, 工学部, 助手 (40040430)
IHARA Hirotaka Faculty of Engineering, Kumamoto University, Associate Professor, 工学部, 講師 (10151648)
SHOSENJI Hideto Faculty of Engineering, Kumamoto University, Assistant Professor, 工学部, 助教授 (80040426)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | Telomer / Polypeptide / Surfactant / Micelle / Bilayer / Helix / Superstructure / 不斉選択性 |
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| Research Abstract |
1. Double-chain alkyl derivatives with poly(L-glutamic acid)- and poly(L-aspartic acid)-head groups were synthesized and their aggregate morphologies in dilute aqueous solutions were investigated. These polyamino acid derivatives were dispersed in water at above pH 4 to form a variety of helical superstructures composed of single-walled bilayer membranes, whose morphologies were closely related to the chemical structures of hydrophilic head groups. The helical structures were not observed in the corresponding ammonium amphiphiles without polyamino acid-head groups and the amphiphile with low-molecular head groups or with poly(DL-amino acid) head groups. The developmental mechanism to helical superstructures was concluded by following the metamorphosis of bilay reaggregates from poly(L-aspartic acid) derivatives in aqueous solutions:the helical forms are induced via the formation of double or multiple helix among the untwisted filaments produced by incubating.
2. Chiral ester cleavage by
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achiral hydroxamic acids was investigated in the presence of chiral matrix micelles formed from amphiphiles with poly-L-lysine-head groups. The results are summarized as follows. (1) The enantioselectivity was not observed in the alkaline hydrolysis in chiral micelles only. This matrix possesses no selectivity. When an achiral hydroxamic acid was added to the system,selectivity was induced. (2) The direction of selectivity is reversed by the conformational change of the secondary structure formed by the peptide moiety of matrix micelles. L-Selectivity in the random coil and D-selectivity in the <alpha> -helix condition were observed. (3) The degree of selectivity is dependent on the chemical structure of hydroxamic acid;for example, an N-H type hydroxamic acid gives higher selectivity than an N-methyl type one. Thus, it is supposed that enantioselectivity is introduced by the chiral interaction between chiral micelles and achiral nucleophiles, in which the conformation of polypeptide moiety plays an important role. Less
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