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Nutritional studies on the metabolic changes due to dietary xenobiotics.

Research Project

Project/Area Number 60470127
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 応用生物化学・栄養化学
Research InstitutionNagoya University

Principal Investigator

YOSHIDA Akira  Professor. School of Agriculture, Nagoya University, 農学部, 教授 (70035377)

Co-Investigator(Kenkyū-buntansha) HORIO Fumihiko  Res. Associate. School of Agriculture, Nagoya University, 農学部, 助手 (20165591)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1985: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsxenobiotics / ascorbic acid(vitamin C) / vitamin E / lipid peroxidation / 過酸化脂質 / コレステロール / アスコルビン酸(ビタミンC) / カテコラミン / チロシン / PCB
Research Abstract

In our industrialized society, we have many chances to take xenobiotics as environmental chemicals, food additives or as medical drugs. Low molecular fat soluble xenobiotics are maily metabolized in liver microsomal mixed function oxidase system, and sometimes show quite similar metabolic effects although their chemical structures are different. In the present project, we found these xenobiotics induce hypercholesterolemia, increase the requirement of some vitamins such as ascorbic acid, vitamin E and A. When rats were fed diets containing PCB, DDT or other xenobiotics, serum levels of cholesterol were significantly elevated. Incorporation of^3H_2O into liver cholesterol, was increased and the activity of hepatic HMC-CoA reductase which is the rate limiting enzyme of cholesterol synthesis was induced by feeding xenobiotics. These results indicate the hypercholesterolemia by dietary xenobiotics is mainly due to the increased synthesis of liver cholesterol. This hypercholesterolemia was accompanied by the increased excretion of urinary catecholamines and <alpha>-blocker suppressed the hypercholesterolemia indicating the involvement of catecholamine in this type of hypercholesterolemia.
Feeding of xenobiotics accelerated the synthesis of ascorbic acid (Vitamin C) in rats and increased the vitamin C requirement in guinea pigs and in a rat mutant unable to synthesize ascorbic acid for maximum induction of hepatic mixed function oxidases. Xenobiotics accelerated the lipid peroxidation in the body and vitamin E and vitamin C were effective to prevent the increment of lipid peroxidation. Platelet aggregation was also stimulated by PCB or DDT probably due to the increased production of thromboxane A_2. In diabetic rats or spontaneously hypertensive rat(SHR), the loss of urinary vitamin C due to xenobiotics was much exergerated than that in normal rats.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] K. Kasai-Kowayashi;A. Yoshida: J. Nutrition. 116. 98-106 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Nagaoka;H. Masaki;Y. Aoyawa;A Yoshida: J. Nutrition. 116. 726-732 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] F. Horio;K. Ozaki;M. Kohmura;A. Yoshida;S. Makino; Y. Hayashi: J. Nutrition. 116. 2278-2289 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Nagaoka;M. Kato;Y. Aoyama;A. Yoshida: Brit. J. Mutrition. 56. 509-517 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] F. Horio;K. Ozaki;H. Oda;S. Makino;Y. Hayashi;A. Yoshida: J. Nutrition. 117. 1036-1044 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Oda;K. Yamashita;K. Sasaki;F. Horio;A. Yoshida: J. Nutrition. 117. 1217-1223 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉田昭, 杉本悦郎(編著): "非栄養素と生体機能" 光生館, 294 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K. Kawai-Kobayashi, A. Yoshida: "Effect of dietary ascorbic acid and vitamin E on the metabolic changes in rats and guinea pigs exposed to PCB." J. Nutrition. 116. 98-106 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Nagaoka, H. Masaki, Y. Aoyama, A. Yoshida: "Effect of excess deetary tyrosine or certain xenobiotics on the cholesterogenesis in rats." J. Nutrition. 116. 726-732 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] F. Horio, K. Ozaki, M. Kohmura, A. Yoshida, S. Makino, Y. Hayashi: "Ascorbic acid requirement for the induction of mucrosomal drug-metabolizing enzymes in a rat mutant unable to synthesize ascorbic acid." J. Nutrition. 116. 2278-2289 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Nagaoka, M. Kato, Y. Aoyama, A. Yoshida: "Comparative studies on the hypercholesterolemia induced by excess dietary tyrosine of polychlorinated biphenyls in rats." Brit. J. Nutrition. 56. 509-517 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] F. Horio, K. Ozaki, H. Oda, S. Makino, Y. Hayashi, A. Yoshida: "Effect of dietary ascorbic acid, cholesterol and PCB on cholesterol concentrations in serum and liver in a rat mutant unable to synthesize ascorbic acid." J. Nutrition. 117. 1036-1044 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Yoshida and E. Sugimoto(Editors): Koseikan Pub. Co. (Tokyo). Nutritional Significance of Non-nutrients, 294 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.K.Kobayashi;A.Yoshida: J.Nutrition. 116. 98-106 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] S.Nagaoka;H.Masaki;Y.Aoyama;A.Yoshida: J.Nutrition. 116. 726-732 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] H.Oda;S.Matsuoka;A.Yoshida: J.Nutrition. 116. 1660-1666 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] S.Nagaoka;M.Kato;Y.Aoyama;A.Yoshida: Brit.J.Nutrition. 56. 509-517 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] F.Horio;K.Ozaki;M.Kohmura;A.Yoshida;S.Makino;Y.Hayashi: J.Nutrition. 116. 2278-2289 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] E.Ohmura;Y.Aoyama;A.Yoshida: Lipids. 21. 748-753 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉田昭,杉本悦郎 編著: "非栄養素と生体機能" 光生館, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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