The Pharmacological study on the species differences in the responses of smooth muscle to vasodilator drugs
| Project/Area Number |
60480085
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎獣医学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KARAKI Hideaki Faculty of Agriculture, The University of Tokyo, 農学部, 助教授 (60011912)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1985: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | Smooth muscle / Vasodilators / Calcium channels / Calcium channel blockers / Calcium channel facilitators / Nitro-ompounds / Species differences / カルシウムチャネル活性薬 |
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| Research Abstract |
Species and regional differences in the response of isolated smooth muscle to vasodilator drugs were examined using isolated rabbit and rat aortae and guinea pig taenia coli. Comparing the contractions induced by either high concentrations of K and receptor agonists in these smooth muscle, it was found that (1) addition of receptor agonists to the muscle maximally activated by high K elicited additional contraction, and (2) in the muscle treated with high K, but not by receptor agonists, Sr and Ba ions entered the cell to elicit contraction. These results suggest the existence of two distinctive Ca channels in these smooth muscles, voltage-dependent channel (VDC) which is activated by membrane depolarization and passes Ca, Sr and Ba, and receptor-linked channel (RLC) which is activated by receptor agonists and passes only Ca. In the next series of experiments, effects of vasodilators on these Ca channels were examined. Ca channel blockers and facilitators relatively selectively modulated the VDC in rabbit aorta although both of the channels were relatively nonselectively affected in rat aorta and guinea pig taenia. In contrast to this, nitro-compounds relatively selectively inhibited RLC in rabbit aorta, relatively nonselectively in rat aorta and had showed little effect in the taenia. The aorta isolated from newborn rabbit showed similar characteristics as those in rat aorta and gradually changed with age. These results suggest the existence of species, regional and age-related changes in the sensitivity of Ca channels to vasodilators in smooth muscle.
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Report
(1 results)
Research Products
(16 results)
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[Publications] KARAKI, H., KISHIMOTO, T., OZAKI, H., SAKATA, K., UMENO, H. & URAKAWA, N.: "Inhibition of calcium channels by harmalin and other harmala alkaloids in vascular and intestinal smooth muscle." British Journal of Pharmacology. 89. 367-375 (1986)
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Related Report
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[Publications] KARAKI, H., NAGASE, H., OZAKI, H. & URAKAWA, N. & WEISS, G.B.: "Effects of calcium channel facilitator, CGP 28,392, on different modes of contraction in smooth muscle of rabbit and rat aortae and guinea-pig taenia caeci." British Journal of Pharmacology. 89. 423-429 (1986)
Description
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Related Report
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