| Project/Area Number |
60480093
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | University of Tokyo |
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Principal Investigator |
TOMODA Isamu Faculty of Agriculture, University of Tokyo, Professor, 農学部, 教授 (00011859)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Kazuo Faculty of Agriculture, Univ. of Tokyo, Assistant Professor, 農学部, 助手 (90134519)
HIROTA Yoshikazu Faculty of Agriculture, Univ. of Tokyo, Assistant Professor, 農学部, 助手 (10134511)
ONO Kenichiro Faculty of Agriculture, Univ. of Tokyo, Assistant Professor, 農学部, 助手 (50111480)
HASEGAWA Atsuhiko Faculty of Agriculture, Univ. of Tokyo, Associate Professor, 農学部, 助教授 (90011923)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1985: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | Cattle / Plasma lipids level / lipid peroxides / 肝臓病変 |
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| Research Abstract |
For the biochemical profile of lipid metabolic disorder due to liver diseases like fatty cow syndrome, the blood and liver were examined on cattle.
The biochemical analysis especially for lipids was carried out on 73 clinically healthy cattle with no gross liver lesions. The plasma lipid peroxides, phospholipid, and cholesterol were significantly correlated to each other, suggesting that the fatty acids received peroxidation in phospholipid and cholesterol which contain large amounts of unsaturated fatty acids. However, no significant correlation was detected between plasma and liver levels of lipid peroxides. The plasma and liver levels of lipid peroxides in cattle were respectively lower rather than those in dogs and pigs. This might be resulted from the lower activities of lipid peroxidation in bovine liver.
In 44 healthy cattle with some gross liver lesions, abnormal levels of plasma lipid components were observed in lipid peroxides(9 cases), phospholipid(8 cases), and triglyceride(12 cases). In 6 cattle with fatty liver by macroscopic examination, abnormal levels of plasma lipid components were detected in 1 case each on phospholipid, free cholesterol, and HDL-cholesterol level. On the other hand, 2 both cases with fatty degeneration examined on liver lipid components revealed to have abnormal levels of liver lipid peroxides and triglyceride.
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