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Experimental Pathology of Granuloma Formation

Research Project

Project/Area Number 60480150
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KYOGOKU Masahisa  Tohoku University School of Medicine, 医学部, 教授 (70025542)

Co-Investigator(Kenkyū-buntansha) KATO Mitsuyasu  Tohoku University School of Medichine, 医学部, 助手 (20194855)
SAWAI Takashi  Tohoku University School of Medicine, 医学部, 助手 (00125577)
NOSE Masato  Tohoku University School of Medicine, 医学部, 助教授 (70030913)
村上 一宏  東北大学, 医学部, 助手 (90190876)
宮沢 正顕  東北大学, 医学部付属病院, 助手 (60167757)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1987: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1985: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsgranuloma / genetic analysis / polyarteritis / synovitis / rheumatoid arthritis / MRL / Mp-1pr / 1pr / 多発性動脈炎 / 遺伝的背景 / Class【II】抗原 / IL-1
Research Abstract

In the socalled "Registered Intractable Diseases", We can find a number of chronic "Granulomatous" inflammations such as rheumatoid arthritis, polyarteritis, other collagen diseases, and even kawasaki disease. The etiopathogenesis of those diseases are still unknown. The purpose of this investgation is to find a clue to elucidate the etiopathogenesis of granulolma, which is mostly composed of macrophages, fibroblast, capillary and lymphocytes. Human cases such as rheumatoid synovitis, proliferated intima of various polyarteritis and animal models including MRL/MP-1pr/1pr mouse, BXSB and C3H/Hej-gld/gld has been the target of our examination.
1) Rheumatoid synovitis: Angiogenesis and proliferation of A cell type synovial cells are conspicuous at the beginning. CD4 T cell immigration and cuffing proliferation around high columnar endothelium are followed by secondary lymph follicle formation, which became the local center of IgG rheumatoid factor and self association immune complex. CD_4 … More cells also made contact with synovial D cells and seemed to introduce a kind of delayed type hypersensitivity in joint. CD8 T cells are few in the site suggesting the ceaseless acceleration of immune network exist in the joint to destroy the hard tissues.
2) Polyarteritis: Proliferation of intima is remarkable in some type of polyarteritis making its prognosis very poor, most of which are granulomatous in nature. The main component of thickend intima is "activated myocyte", which proliferated in the media changing into secretory form after various growth factor stimulation, then immigrated to the intima where secrete various kinds of matrix one after another. GM1 ganglioside is a good marker of proliferation and the studies about the relation between genetic expression of cell marker,ie. development,and proliferation are going on at present.
3)MRL/Mp-1pr/1pr mouse: Arthritis, arteritis and glomerulitis of MRL/1 mouse are all granulomatous. macrophages stimulated and activated towards wrong direction by lpr dependent Thy 1.Ly 5+lymphocyte must be blamed as a major player in site to introduce marked tissue destruction. lpr gene (Yaa and gld genes either) seemed to be just a accerelator gene of such granulomatous lesion and socalled nephritogenic as well as vasculitogenic genes must be exist separately in the background gene complex. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 京極方久: 日本病理学会誌. 74. 13-60 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M. Kyogoku;M. Nose;T. Sawai et al.: Animal models;assessing the scope of their use in biomedical research (Ed. Kawamata and Melby)Alan R. Liss., Inc. New York. 95-130 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M. Miyazawa:M. Nose;M.Kawashima;M.Kyogoku: Journal of Experimental Medicine. 166. 890-908 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Sawai;S. Hara;T. Mitomo;M. Kyogoku: Mixed connective tissue disease and antinuclear antibodies (Ed. Kasukawa and Sharp)Excerpta Medica, Amsterdam. 291-296 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masahisa Kyogoku: Kawasaki Disease (Ed. Shulman)Alan R. Liss., Inc. New York. 257-273 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Mori;T. Sawai;T. Teshima;M. Kyogoku: Journal of Histochemistry and Cytochemistry. 36. 111-114 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masahisa Kyogoku;Hans Wigzell: "New Horizons in Animal Models for Autoimmune Disease" Academic Press Inc., 369 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masahisa Kyogoku, Masato Nose, Takashi Sawai et al.: "Immunopathology of murine lupus -overview and SL/Ni, MRL/Mp-1pr/1pr" Animal models -assessing the scope of their use in biomedical research (Ed. Kawamata and melby) Alan R. Liss inc., New York. 95-130 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masaaki Miyazawa, Masato Nose, Masaji Kawashima and Masahisa Kyogoku: "Pathogenesis of arteritis of SL/Ni mice -Possible lytic effect of anti-gp 70 antibodies on vescular smooth muscle cells-" Journal of Experimental Medicine. 166. 890-908 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi Sawai, Shigeko Hara, Toshio Mitomo and Masahisa Kyogku: "Histopathological studies on the kidney, skin and synovial tissue of MCTD" Mixed Connective Tissue Disease and Anti-nuclear Antibodies (Ed. Kasukawa and Sharp) Excerpta Medica, Amsterdam. 291-296 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masahisa Kyogoku: "A pathological analysis of Kawasaki disease -with some suggestions of its etiopathogenesis" Kawasaki Disease (Ed. Shulman) Aran R. Liss, Inc., New York. 257-273 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shiro Mori, Takashi Sawai, Teiichi Teshima and Masahisa Kyogku: "A new decalcifying technique for immunohistochemical studies of calcified tissue, especially applicable to surface marker demonstration" Journal of Histochemistry and Cytochemistry. 36. 111-114 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masahisa Kyogoku and Hans Wigzell: Academic Press Inc.New Horizons in Animal Models for Autoimmune Disease, 369 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 京極方久: 代謝. 23. 3-13 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 京極方久: 最新医学. 41. 2004-2013 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 京極方久: 実験医学. 4. 25-32 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 京極方久: 感染・炎症・免疫. 17. 15-30,42-43 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 村上一宏,能勢真人: 免疫薬理. 4. 157-164 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nose,M.;Tachiwaki,O.;Kyogoku,M.: New Horizon in Animal Models for Autoimmune Disease. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Wigzell,H.;Kyogoku,M.: "New Horizons in Animal Models for Autoimmune Disease" Academic Press, 500 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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