| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1985: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Research Abstract |
The present project has investigated the usefulness of several serum and urine markers for collagen metabolism as an indicator for arteriosclerosis, because arteriosclerosis involves the alterations of blood vessels wall, that is, the accumulation of type <III> collagen and basement membrane components. Therefore, serum type <III> procollagen peptide as an indicator for biosynthesis of type <III> collagen, serum laminin as an indicator for biosynthesis of basement membrane glycoprotein, and urinary hydroxy proline excretion were investegated in relation with arteriosclerosis. 121 health-checked subjects (84 males and 37 females) and 28 male patients with diabetes mellitus without any diabetic complications were studied. Serum total cholesterol and triglyceride were not correlated with their arteriosclerotic changes on optic fundi and electrocardiogram and proved to be inappropriate for arteriosclerotic indicator. Urinary hydroxyproline excretion and serum levels of type <III> procollagen peptide were slightly higher among older-aged males but not correlated with arteriosclerotic changes. On the other hand, serum laminin values were higher among older aged males and females. Nonetheless, there was a higher tendency of the serum laminin values among arteriosclerotic cases compared to those of non-arteriosclerotic cases without statistical significance. Serum laminin values showed significant positive correlations with age (r=0.231, p 0.05), serum total cholesterol (r=0.330, p 0.01) and triglyceride (r=0.241, p 0.05). These findings suggested that the serum laminin value can be useful indicator for arteriosclerosis, because it may reflect increased biosynthesis of basement membrane.
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