| Project/Area Number |
60480200
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | University of Tokyo, School of Medicine |
|---|
Principal Investigator |
MIYAMOTO Terumasa Univ. of Tokyo, School of Med., 医学部, 教授 (80010239)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Hazime same as above, Assistant, 医学部・物療内科, 助手 (80171578)
MORITA Yutaka same as above, Assistant, 医学部・物療内科, 助手 (60107620)
OHTA Ken same as above, Assistant, 医学部・物療内科, 助手 (30160500)
KUDO Koichiro same as above, Medical staff, 医学部・物療内科, 医員 (20107618)
ISHII Akira Univ. of Tokyo, School of Medicine, Medical staff, 医学部・物療内科, 医員 (30272553)
|
|---|
| Project Period (FY) |
1985 – 1986
|
| Project Status |
Completed (Fiscal Year 1986)
|
| Budget Amount *help |
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Bronchial athma / hyperreactive airway / 気管支喘息 |
|---|
| Research Abstract |
In order to study the part of etiological mechanism of bronchial asthma, hyperreactive colony of guinea pig was tried to be established. Various concentration of histamine was nebulized into the box in which guinea pigs were put. In this way hyperreactive and hyporeactive guinea pigs were selected.
Reactivity of tracheal ring was well correlated with the in vivo reactivity. Reactivity has become less with the ages and also with the gold injection. Hyperreacive and hyporeactive groups were inbred among each group.
<F_1> bred between hyperreactive guinea pigs were not necessarily hyperreactive and some of them were even hyporeactive. Hyperreactive guinea pigs were selected among <F_1> and <F_2> was born from hyperreactive pairs, and <F_3> was produced in the same way. Similarly hyporeactive descendants were made.
With these procedures hyperreactive and hyporeactive guinea pigs were selected but the number of birth became less and less, and they became weaker than original one. This project will be persude further.
|
