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ROLE OF SUPEROXIDE FROM MACROPHAGES IN HEPATIC FIBROSIS

Research Project

Project/Area Number 60480207
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionUniversity of Tokyo

Principal Investigator

FUJIWARA Kenji  University of Tokyo, Faculty of Medicine, 医学部, 助手 (80101088)

Co-Investigator(Kenkyū-buntansha) OGATA Itsuro  University of Tokyo, Faculty of Medicine, 医学部, 医員 (80169169)
OHTA Yasuhiko  University of Tokyo, Faculty of Medicine, 医学部, 助手 (60124666)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1986: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1985: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsHepatic fibrosis / Collagen / Macrophage / Superoxide / アラビアゴム
Research Abstract

The aim of this project is to investigate a role of superoxide from macrophages in the process of hepatic fibrosis.
The following results have been obtained.
1) When rats with hepatic fibrosis induced by dimethylnitrosamine administration received injections of arabic gum, a polysaccharide with hydroxyproline, macrophages swollen with vacuoles accumulated along increased hepatic fibers. Hepatic collagen synthesis was reduced after arabic gum adnimistration which stimulated rats to release superoxide from peritoneal macrophages. In case of other polysaccharides and latex particles, there was no such findings.
2) Superoxide dismutase injections did not affect hepatic collagen synthesis in rats given dimethylnitosamine.
From these, macrophages might play a role in inhibiting collagen synthsis in hepatic fibrosis. The significance of activated macrophages accumulated after arabic gum administration remains to be investigated. As the role of superoxide in collagen synthesis has not been proved in vivo, experiments in vitro should be carried out using a co-culture system of isolated hepatic fibroblasts with Kupffer cells from varying liver injuries.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Ogata,Itsuro: Life Sciences. 37. 2269-2273 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kubota,Yasuo: British J.Dermatology. 113. 559-563 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Fujiwara,Kenji: in submission.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Fujiwara,Kenji: "Irreversibility and treatment of hepatic fibrosis in rats.In:Pathobiology of hepatic fibrosis." Elsevier Science Publishers, 232 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata, I.: "Collagen accumulation can continue with decreased prolyl hydroxylase activity in the liver" Life Sciences. 37. 2269-2273 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kubota, Y.: "Collagen prolyl hydroxylase inhibitor and reduced collagen formation in cotton pellet-induced granuloma and skin wound healing in rats" Bri J. Dermatol.113. 559-563 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Fujiwara, K.: "Suppresion of hepatic fibrosis by arabic gum in rats intoxicated with dimethylnitrosamine: Possible role of activated macrophages" (in submission).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Fujiwara, K.: Elsevier Science Publishers, "Pathobiology of Hepatic Fibrosis". Irreversibility and treatment of hepatic fibrosis in rats, 217-223 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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