| Project/Area Number |
60480209
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
FURUTA Seiichi Shinshu University School of Medicine, 2nd Department of Medicine, 医学部, 教授 (20020852)
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| Co-Investigator(Kenkyū-buntansha) |
GIBO Yukio ditto, 医学部第二内科学教室, 助手 (40161616)
SODEYAMA Takeshi ditto, 医学部第二内科学教室, 講師 (00163139)
KIYOSAWA Kendo ditto, 医学部第二内科学教室, 助教授 (30020829)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1985: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Non-A / non-B hepatitis / Hepatitis virus / Chronic hepatitis / Liver cirrhosis / Posttransfusion hepatitis |
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| Research Abstract |
Non-A,non-B hepatitis virus(es) has not yet been identified. This study was to investigate the etiological agent(s) of non-A,non-B hepatitis in a special way hitherto not reported. We have tried to detect the virus(es) in the hepatocytes and lymphocytes of primary culture after being obtained from patients with non-A,non-B hepatitis, However, until now we could not find any responsible agent by this method. Further modifications of the culture medium or culter conditions seem to be needed.
Next, the epidemiological study on viral hepatitis revealed that the prevalence of non-A,non-B hepatitis was the highest among the acute sporadic viral hepatitis, that accounted for approximately 40 % of them, and posttransfusion hepatitis was exclusively of non-A,non-B hepatitis so far experienced over the past 2 years. Non-A,non-B hepatitis of both sporadic and posttransfusion category was found not infrequently to have a chronicity. However, the longitudinal follow-up study for these patients revealed that they did not show a rapid progression to cirrhosis as observed in some of the patients with chronic hepatitis type B. Further longer follow-up study will be needed to clarify the long-term outcome of these patients.
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