| Project/Area Number |
60480212
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | EHIME UNIVERSITY |
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Principal Investigator |
OHTA YASUYUKI EHIME UNIVERSITY, PROFESSOR, 医学部, 教授 (40033055)
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| Co-Investigator(Kenkyū-buntansha) |
HORIIKE NORIO EHIME UNIVERSITY, ASSISTANT, 医学部, 助手 (90173624)
ONJI MORIKAZU EHIME UNIVERSITY, LECTURER, 医学部附属病院, 講師 (10112260)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | Hepatitis B Virus DNA / Prednisolone / Chronic Hepatitis Type B / HBV-DNAの肝細胞核内への組込み |
|---|
| Research Abstract |
IN ORDER TO CLARIGY THE INTEGRATION OF HEPATITIS B VIRUS (HBV-DNA) INTO THE LIVER CELL DNA AND REPLICATION OF HBV FOLLOWING ADMINISTRATION OF GLUCOCORTICOID(PREDNISOLONE, PSL), WE INVESTIGATED THE CHANGE OF HBV-DNA IN SERA AND LIVERS IN PATIENTS WITH HBEAG POSITIVE CHRONIC HEPATITIS TREATED WITH PSL.
HBV-DNA IN SERA INCREASED FOLLOWING PSL ADMINISTRATION. THREE WEEKS AFTER PSL USE THE INCREASE OF HBV-DNA BECAME MAXIMUM AND THE INCREASED RATIO WAS 3.2 TIMES BEFORE THE TREATMENT.
ALTHOUGH FREE HBV-DNA IN LIVERS INCREASED BY PSL, THE INTEGRATION OF HBV-DNA INTO LIVER CELL DNA WAS NOT NEWLY DETECTED.
PSL PROGRESS THE REPLICATION OF HBV TEMPORALLY, BUT IT WAS NOT INCREASE THE INTEGRATION OF HBV-DNA INTO LIVER CELL DNA, SO THE RISK OF CANCER OCCURENCE MAY BE LITTLE OR NONE.
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