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Mechanism of pulmonary vascular injury in high altitude pulmonary edema.

Research Project

Project/Area Number 60480216
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionShinshu University School of Medicine

Principal Investigator

KUSAMA Shozo  Shinshu University School of Medicine Professor, 医学部, 教授 (70020708)

Co-Investigator(Kenkyū-buntansha) SAKAI Akio  Shinshu University School of Medicine Assistant, 医学部, 助手 (70020758)
UEDA Gou  Shinshu University School of Medicine Professor, 医学部, 教授 (10020702)
KUBO Keishi  Shinshu University School of Medicine Assistant, 医学部, 助手 (80143965)
KOBAYASHI Toshio  Shinshu University School of Medicine Assistant Professor, 医学部, 講師 (80020775)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1986: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1985: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsHigh altitude / Pulmonary edema / Artificil climatic chanber / Thromboxane <A_2> / Decompression / Denitrogenation / 肺空気塞栓
Research Abstract

To examine the hypothesis that high altitude pulmonary edema might be caused by intravascular air bubble formation during decompression, two experiments were performed by using awake sheep with chronic lung lymph fistula.
1) Effects of thromboxane synthase inhibition on air emboli lung injury in sheep. We tested the effects of OKY-046, a thromboxane synthase inhibitor, on lung injury induced by 2 hour of pulmonary air infusion in the pulmonary artery. Air infusion caused sustained pulmonary hypertension and an increase in pulmonary vascular permeability. The levels of <TxB_2> and 6-keto- <PGF_(1(alpha))> in both plasma and lung lymph were significantly elevated during the air infusion. <TxB_2> concentration in plasma obtained from the left atrium was higher than that from the pulmonary artery at 15 min of air infusion. When sheep were pretreated with OKY-046(10mg/kg, iv) prior to the air infusion, increases in <TxB_2> were prevented. The pulmonary arterial pressure, however, increased s … More imilarly to that of untreated sheep. The increase in lung lymph flow was significantly supressed during the air infusion. These data suggest that the pulmonary hypertension observed during air embolism is not caused by <TxA_2> . We also tested the effects of dibutyryl cyclic AMP on air emboli lung injury in awake sheep.
2) Effects of hypobaria on lung fluid balance in awake sheep during rapid exposure to 6600m-simulated high altitude. We observed that under both 6600m-simulated hypoxic hypobaria (barometric pressure 326mmHg, <FIO_2> 0.21) and 6600m-simulated normoxic hypobaria (barometric pressure 326mmHg, <FIO_2> 0.65), lung lymph flow significantly increased. But exposure to 6600m-simulated normoxic hypobaria (barometric pressure 326mmHg, <FIO_2> 0.65) after pretreatment with a 2 hour-pure oxygen inhalation caused no changes in lung lymph flow. These results suggest that rapid exposure to hypobaria causes an increase in pulmonary vascular permeability and that intravascular air bubble formation might account for this permeability change. Less

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Fukushima M;Kobayashi T.: J Appl Physiol. 60. 1828-1833 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kobayashi H;Kobayashi T;Fukushima M: J Appl Physiol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hirai K;Kobayashi T;Kubo K;Shibamoto T.: J Appl Physiol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Levine DB;Kubo K;Kobayashi T;Fukushima M;Shibamoto T;Ueda G.: J Appl Physiol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 小林俊夫他: カレントテラピー. 5. 143-148 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 上田五雨他: 臨床スポーツ医学. 3. 589-592 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Fukushima M, Kobayashi T.: "Effects of thromboxane synthase inhibition on air emboli lung injury in sheep." J Appl Physiol. 60. 1828-1833 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kobayashi H, Kobayashi T, Fukushima M.: "Effects of dibutyryl cyclic AMP on pulmonary air embolism-induced lung injury in awake sheep." J Appl Physiol. in press. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hirai K, Kobayashi T, Kubo K, Shibamoto T.: "Effects of hypobaria on lung fluid balance in awake sheep during rapid exposure to 6600m-simulated high altitude." J Appl Physiol. in submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Levine DB, Kubo K, Kobayashi T, Fukushima M, Shibamoto T, Ueda G.: "The role of barometric pressure in pulmonary fluid balance and oxygen transport." J Appl Physiol. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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