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Factors contributing to increases in circulating hypertensive peptides in genetic hypertension

Research Project

Project/Area Number 60480233
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKyushu University

Principal Investigator

TAKESHITA Akira  Kyushu University, Faculty of Medicine, associate professor, 医学部, 助教授 (30038814)

Co-Investigator(Kenkyū-buntansha) IMAIZUMI Tsutomu  Kyushu University, Faculty of Medicine, Assistant, 医学部, 助手 (60148947)
KANAIDE Hideo  Kyushu University, Faculty of Medicine, Lecture, 医学部, 講師 (80038851)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1986: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1985: ¥4,700,000 (Direct Cost: ¥4,700,000)
KeywordsCardiopulmonary baroreflex / High salt intake / Spontaneously hypertensive rat / Atrial natriuretic peptide / 心房筋伸展
Research Abstract

1) We investigated the effects of high salt intake on cardiopulmonary baroreflex control of renal sympathetic nerve activity (RSNA) in SHR and WKY. The stimulus ( <DELTA> LV end-diastolic pressure)-response ( <DELTA> RSNA) relationship in SHR with normal salt intake was shifted toward a higher pressure range compared with that in WKY with normal salt intake. High salt intake decereased the gain of the reflex both in SHR and WKY. However, changes in the gain caused by salt loading were comparable between SHR and WKY.
2) We also examined release of atrial natriuretic peptide (ANP) in response to atrail stretch in vitro. We found, first, that ANP release decreased gradually with time despite that an increase in resting tension was maintained, Which suggests that adaptation occures in ANP release in response to atrial stretch. Second, we found that ANP release did not occure when the atria were stretched in the medium with diltiazem <10^(-5)> M or the calciums-free medium. However, repetitive stretch at a frequency of 300 beats/min increased ANP release despite the presence of diltiazem <10^(-5)> M. These results indicate that active muscle contraction or calcium entry into myocytes is not prerequisite for ANP release.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Imamura T;Takeshita A;Yamamoto K;Ashihara T;Nakamura M;HoKa S: Circulation. 71. 11-16 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Higuchi S;Takeshita A;Ito N;Imaizumi T;Matsuguchi H;Nakamura M: Circulation Research. 57. 244-251 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ito N;Takeshita A;Higuchi S;Nakamura M: Hypertension. 8. 142-146 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Higuchi S;Takeshita A;Higashi H;Ito N;Imaizumi T;Matsuguchi H;Nakamura M: American Journal Physiology. 250. H226-H230 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Takeshita A;Jongu S;Imaizumi T;Koyanagi S;Yamamoto K;Nakamura M: Circulation Research. 59. 43-48 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura M;Takeshita A;Nose Y;Hirosawa K;Toshima H;Hosoda S;Hayakawa K;Yamaguchi H;Inoue M;Hiramori K: Circulation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Imamura T, Takeshita A, Yamamota K, Ashihara T, Nakamura M, Hoka S.: "Digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in man." Circulation. 71. 11-16 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Higuchi S, Takeshita A, Ito N, Imaizumi T, Matsuguchi H, Nakamura M.: "Arterial pressure and heart rate responses to calcium channel blockers administrated in the brainstem in rats." Circulation Research. 57. 244-251 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ito N, Takeshita A, Higuchi S, Nakamura M.: "Venous abnormality in normotensive young men with family history of hypertension." Hypertension. 8. 142-146 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Higuchi S, Takeshita A, Higashi H, Ito N, Imaizumi T, Matsuguchi H, Nakamura M.: "Lowering calcium in the nucleus tractus solitarius causes hypotension and bradycardia." American Journal Physiology. 250. H226-H230 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Takeshita A, Jingu S, Imaizumi T, Koyanagi S, Yamamoto K, Nakamura M.: "Augmented cardiopulmonary baroreflex control of forearm vascular resistance in young athletes." Circulation Research. 59 (1). 43-48 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura M, Takeshita A, Nose Y, Hirosawa K, Toshima H, Hosoda S, Hayakawa K, Yamaguchi H, Inoue M, Hiramori K.: "Clinical characteristics associated with myocardial infarction, arrhythmias and sudden death in patients with vasospastic angian" Circulation.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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