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Pathogenesis and protection of brain damage in the severe cerebral palsy.

Research Project

Project/Area Number 60480247
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTottori University

Principal Investigator

TAKESHITA Kenzo  Tottori University, Professor, 医学部, 教授 (90037375)

Co-Investigator(Kenkyū-buntansha) TOMITA Yutaka  Tottori University Assistant, 医学部附属病院, 助手 (00127523)
ANDO Yukinori  Tottori University, Assistant, 医学部, 助手 (90168047)
NAKANO Chizuko  Tottori University, Assistant, 医学部, 助手 (90164251)
IESHIMA Atsushi  Tottori University, Assistant, 医学部, 助手 (30144661)
MITO Takashi  Tottori University, Assistant, 医学部, 助手 (00166068)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsCerebral palsy / Perinatal brain damage / 多発生脳軟化 / 未熟児 / ピペコリン酸 / 未熟児脳障害 / 短潜時感覚誘発反応
Research Abstract

Advances in obstetric technology and neonatal intensive care such as fetal heart rate monitoring or phototherapy have certainly contributed to the recent reduction in the incidence of cerebral palsy. This significant decrease was mainly related to the syndrome of a spastic hemiplegia and tension athetosis, both of which concern perinatally acquired forms of cerebral palsy.Etiology and pathogenesis of cerebral palsy are of course very hetrogeneous conditions. However, their pathogenosis is not clearly resolved. In pathogenosis of remained brain damage followed by prematurity, intraventricular hemorrhage which is a frequent cause of morbidity arises mostly from subependymal hemorrhage, rarely from hemorrhages in periventricular white matter or choroid plexus. These periventricular-intraventricular hemorrhages are actually vascular accidents based on vascular immaturity. In addition to predisposing pathogenetic factors of anatomical and hemodynamic immaturity there are important causing factors which induce cerebral hypoperfusion and hyperperfusion accompanied with venous pressure increase. The continuous monitoring of periventricular CBF and venous pressure may elucidate the mechanism of early or late onset of subependymal hemorrhage / intraventricular hemorrhage or their progression.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Ando Y;Takashima S and Takeshita K: Brain Dev.7. 385-391 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mito T;Tanaka T;Becker L E;Takashima S;Takeshita K: Arch Neurol. 43. 677-680 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tomita Y;Nishimura S;Tanaka T.: EEG Clin Neurophysiol. 65. 335-343 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeshota K.: Yonago Acta medica. 30. 107-114 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakajima M;Takashima S;Takeshota K.: Acta Pediatr Scand. 76. 766-768 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tanaka T;Tomita Y;Nishimura S: J Child Neurol. 2. 287-292 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ando Y;Takashima S;Takashita K: "Cerebral blood changes during 12 hours after birth. In maeda K ed. The Fetus as a Patient. International Congress Series. 752" Amsterdam New Yord, Oxford:Excepta Medica, (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] TAkashoma S;Ohno K;Ando Y: "Pathogenesis of perinatal leukomalacia. In Yabuuchi H et eds. Neonatal Brain and Behaviar." Nagoya:Uni of Nagoya Press, (1978)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mito T, Tanaka T, Becker L E, Takashima S, Takeshita K.: "Infanitile bilateral striatal necrosis; Clinico-pathological classification." Arch Neurol. 43. 677-680 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tomita Y,Nishimura S, Tanaka T.: "Short latency SEPs in infants and children; Developmental changes and maturational index of SEPs." EEG Clin Neurophysiol. 65. 335-343 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeshita K.: "Comprehensive approach to developmental disabilities in Japan." Yonago Acta Medica. 30. 107-114 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakajima M, Takashima S, Takeshita K.: "Plasma pipecolic acid concentration normal pregnant woman, children and adult." Acta Pediatr Scand. 76. 766-768 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tanaka T, Tomita Y, Nishimura S.: "Prognostic significance of the electrically elicited blink reflex in neonates." J Child Neurol. 2. 287-292 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashima S, Ohno K, Ando Y.: Nagoya; Uni of Nagoya Press. Pathogenesis of perinatal leukomalasia., 45-52 (1978)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tomita Y;Nishimura S;Tanaka T.: Electroencephalography and clinical Neurophysiology. 65. 335-343 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tanaka T;Tomita Y;Nishimura S.: Journal of child Neurology. 1. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakajima M;Takashima S;Takeshita K.: Acta Paediatrica Scandinavica. 76. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nishimura S;Tomita Y;Tanaka T;Kasagi S;takashima S;Takeshita K.: Brain&Development. 8. 6-9 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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