| Project/Area Number |
60480251
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | School of Medicine, Keio University |
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Principal Investigator |
NISHIKAWA T. Department of Dermatology, Keio University School of Medicine, 医学部, 教授 (50051579)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Y. Department of Dermatology, Keio University School of Medicine, 医学部, 兼任講師 (80138081)
HAYAKAWA K. Department of Dermatology, Keio University School of Medicine, 医学部, 助手 (50146669)
SHIMIZU H. Department of Dermatology, Keio University School of Medicine, 医学部, 助手 (00146672)
HASHIMOTO T. Department of Dermatology, Keio University School of Medicine, 医学部, 助手 (20129597)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | Pemphigoid / pemphigus / 天疱瘡 / 細胞表面マーカー / 浸潤細胞 |
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| Research Abstract |
In 1985th academic year, the immunohistochemical technique for the detection of cell surface markers was established. At the same time, the patients with pemphigoid and pemphigus were followed up for the study. In 1986th academic year, the infiltrated cells of cutaneous lesions from 6 patients with pemphigoid and 5 patients with pemphigus were characterized using monoclonal antibodies and an indirect peroxidase technique. In some patients, subsets of peripheral blood lymphocytes were also examined. T cells and Ia positive cells were present in abundance but no B cells were detected. Both helper and suppressor T cells were found in the involved and marginal skin with predominance of helper T cells. From these data, one can speculate some positive role of T cells for the blister formation. However, the direct role of infiltrated lymphocytes awaits further study.
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