| Project/Area Number |
60480255
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Fukui Medical School (1986)
Kyoto University (1985) |
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Principal Investigator |
KANJI Torizuka Fukui Medical School, 国立大学(その他), その他 (00025537)
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| Co-Investigator(Kenkyū-buntansha) |
YASUSHI Ishii Faculty of Medicine, Fukui Medical School, 医学部, 教授 (00026949)
HIDEO Saji Faculty of Medicine, Kyoto University, 医学部, 助手 (40115853)
YOSHIHARU Yonekura Faculty of Medicine, Kyoto University, 医学部, 助手 (60135572)
HARUMI Itoh Faculty of Medicine, Kyoto University, 医学部, 助教授 (40026943)
AKIRA Yokoyama Faculty of Pharmaceutical Sciences, Kyoto University, 薬学部, 教授 (90025685)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1986: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1985: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | positron emission tomography / nuclear medicine / myocardial perfusion / myocardial metabolism / myocardial ischemia / 循環器病診断 |
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| Research Abstract |
We have studied on basic research and clinical application of positron emission tomography (PET) for the diagnosis of coronary artery disease.
1. Evaluation of regional myocardial perfusion
(1) Myocardial PET with N-13 ammonia: N-13 ammonia provided superior tomographic images of myocardial perfusion at rest and during exercise because of high extraction and long retention of the tracer, resulting in accurate diagnosis of coronary artery disease and identification of myocardial ischemia. Introduction of oblique angle tomograms and quantitative analysis seemed to improve the diagnostic accuracy.
(2) Measurement of regional myocardial blood flow using 0-15 water: Regional myocardial blood flow was evaluated using 0-15 water and a new sbtraction method of blood pool activities measured by inhalation of 0-15 CO.
2. Regional myocardial glucose metabolism
Regional glucose metabolism was evaluated with F-18 fluorodeoxyglucose comparing with myocardial perfusion. Increased exogenous glycolytic flux was observed not only in resting ischemia but also in exercise induced ischemic myocardium, suggesting the possible alteration of myocardial energy metabolism.
The present study demonstrated that PET offers superior diagnostic capability compared with conventional nuclear medicine technique as well as unique information for the diagnosis in cardiology.
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