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Studies on the functions of the actirated lymphocytes after partial hepatectomy

Research Project

Project/Area Number 60480293
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionOkayama University

Principal Investigator

TANAKA Noriaki  Assistant Prof., Hospital of Okayama University Medical School, 医学部, 講師 (10127566)

Co-Investigator(Kenkyū-buntansha) KAMIKAWA Yasuaki  Hospital of Okayama University Medical School, 医学部付属病院, 助手 (00152851)
MIMURA Hisashi  Associated Prof., Okayama University Medical School, 医学部, 助教授 (80116508)
ORITA Kunzo  Professor, Okayama University Medical School, 医学部, 教授 (20033053)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1985: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordspartial hepatectomy / regenerating liver cells / lymphokine activated killer / nonparenchymal liver cells / IL-2産生能 / 摘脾
Research Abstract

We observed that activity of natural killer (NK) cells and in vitro inducibility of lymphokine activated killer (LAK) cells were augmented by partial hepatectomy (HEP) in the spleen cells of C3H mice. LAK cells induced from spleen cells of hepatectomized mice (HEP-LAK) were cytotoxic not only against tumor cell lines but also against parenchymal cells of regenerating liver (hepatoblasts) and lectin induced lymphoblasts. Further more, it was found that IL-2 production of spleen cells was also augmented by HEP. Therefore, we examined the possibility that LAK cells cytotoxic against hepatoblasts are induced in vivo in the regenerating liver. Non-parenchymal cells of liver and spleen cells obtained from normal mice exhibited little cytotoxicity against hepatoblasts. The activities were remarkably augmented by daily administration of IL-2 after HEP. Non-parenchymal liver cells of rat in which parenchymal cells are completely eliminated by density gradient centrifugation exhibited high cytotoxic activity against hepatoblasts. When rats were previously subjected to splenectomy, the activity of non-parenchymal cells after HEP were weakened. Cytostatic activity of HEP-LAK cells was examined in vivo experimental systems. HEP-LAK cells injected intradermaly suppressed epidermal proliferation stimulated by cholera toxin. HEP-LAK cells injected intravenously suppressed Tritium thymidine uptake of the regenerating liver. From above results, it was suggested that lymphocytes are able to regulate proliferation of normal epithelial cells including epidermal cells and liver cells, and play a role of auto-organization.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Minoru Ono;Noriaki Tanaka;Kunzo Orita: Cancer Research. 46. 5049-5053 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 小野稔,卜部貴光,紙谷晋吾,雁木淳一,田中紀章,折田薫三: 消化器と免疫. 17. 119-123 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 小野稔,池村栄作,田中紀章,折田薫三: 医学のあゆみ. 140. 57-58 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 池村栄作,小野稔,卜部貴光,雁木淳一,紙谷晋吾,田中紀章,折田薫三: 医学のあゆみ. 140. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 池村栄作: 最新医学. 4. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hisashi Yoshihara;Noriaki Tanaka;Kunzou Orita: Acta Medica Okayama. 40. 113-119 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 折田薫三,田中紀章: "臨床免疫学序説(腫瘍に対する免疫監視機構の展望)" 科学評論社, (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Minoru Ono, Noriaki Tanaka, Kunzo Orita: "Complete Regression of Mouse Hepatoma Transplanted after Partial Hepatectomy and the Immunological Mechanism of Such Regression" Cancer Research. 46. 5049-5053 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hisashi Yoshihara, Noriaki Tanaka, Kunzo Orita: "Supprestion of Natural Killer Cell Activity by Surgical Stress in Cancer Patients and the Underlying Mechanisms" Acta Medica Okayama. 40. 113-119 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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