| Project/Area Number |
60480295
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
ISHIBIKI Kyuya School of Medicine, Keio University, 医学部, 助教授 (10051236)
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| Co-Investigator(Kenkyū-buntansha) |
下山 豊 慶應義塾大学, 医学部, 助手
AIKAWA Naoki School of Medicine, Keio University, 医学部, 助手 (40110879)
SHIMOYAMA Yutaka School of Medicine, Keio University
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1985: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Surgical stress / Antibiotics / Pharmacokinetics / 腎機能 |
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| Research Abstract |
Fluctuation of pharmacokinetics of antibiotics caused by surgical stress of gastrectomy was studied useing ceftazidime(CAZ), cefotiam(CTM) and netylmicin(NTL). Blood levels of CAZ, T1/2 <beta> and AUC were significantly lower after operation rather than those before operation. CTM showed the same tendency without significance. These decreases went up to normal values till 3 POD. NTL revealed the lower blood levels, T1/2 <beta> and AUC with the lower urinary excretion. NAG,B2MG which indicated the disfunction of tubles of kidney increased gradually to 3 POD. The results suggested the temporary and latent kidney disfunction caused by NTL.
These data also indicate the consideration on clinical administration design of antibiotics in peri-operative period.
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