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Experimental and Clinical Studies on Transplantation of the Pancreas

Research Project

Project/Area Number 60480304
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionNagasaki University

Principal Investigator

TSUNODA Tsukasa  Nagasaki University, School of Medicine, Assistant Professor, 医学部, 講師 (00110841)

Co-Investigator(Kenkyū-buntansha) MOTOSHIMA Koichi  Nagasaki University, School of Medicine, Assistant Professor, 医学部, 助手 (00182171)
酒井 秀則  長崎大学, 医学部付属病院, 医員
SAKAI Hidenori  Nagasaki University, School of Medicine
小原 則博  長崎大学, 医学部付属病院, 医員
山口 孝  長崎大学, 医学部, 講師 (10133175)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1985: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsExperimental transplantation of pancreatic islet / Experimental segmental transplantation of pancreas / Clinical autotransplantation of pancreatic islet / Clinical segmental autograft of pancreas / Segmental pancreas transplantation accompanied with spleen / Segmental pancreas transplantation with pancreaticocystostomy / Pancreatic islet transplantation with chronic pancreatitis / 移植膵静脈血栓 / 膵組織片自家移植 / 残存膵再生 / 膵部分自家移植 / 膵空腸吻合術 / 膵膀胱吻合術 / 膵自家移植の臨床
Research Abstract

Experimental and clinical studies on pancreatic transplantation conducted at the 2nd Department of Surgery for the last 3 years were reported.
A) Experimental studies
1) Did transplanted pancreatic islets from chronic pancreatitis maintain normal glucose levels in dogs?
Chronic pancreatitis was induced by injection of Freund's' complete adjuvant in 12 mongrel dogs. They were totally pancreatomized, and then all islet cells of the each dog were transplanted into the splenic pulp ofd the each dog respectively. The endocrine funcion was disturbed soon after islet transplantation in the dogs with severe fibrosis of the pancreas and the glucose level did not maintain normal.
2) Was it necessary to drain the pancreatic ductal system in the dogs with segmental pancreas transplantation?
Segmental pancreas transplantation with pancreaticojejunostomy or pancreatico-cystostomy after total pancreatectomy was done on 11 dogs. All dogs showed normal endocrine function for a long time without pancreatic f … More ibrosis. Although segmental pancreas transplantation with intraperitoneal drainage or duct occlusion using neoprene was done on 8 dogs, all dogs showed progressive disturbance of pancreatic function with severe fibroses .
3) How to prevent throbosis of the splenic vein in the dogs with segmental pancreas transplantation?
Segmental pancreas transplantation accompanied with spleen or splenic arteriovenous shunt without spleen was done an 15 dogs. In thase dogs. No Vasccelar thrcmbosis was seen. Although segfmental transplantation without spleen or arteriovenous shunt was done on 8 dogs, 50 of the dogs had vascular thrombosis and resulted in graft failure.
B) Clinical studies.
On the basis of those experimental results, pancreas islet autotransplantation and segmental pancreatic autograft were clinically done on 4 patients with chronic pancreatitis and 5 patients with pancreatoduodenal cancer. Four patients with chronic pancreatitis underwent subtotal distal pancreatectomy with islet transplantation and 3 with pancreatoduodenal cancer underwent total pancreatectomy with islet transplantation. One patient with carcinoma of the pancreas received segmental pancreatic autograft after total pancreatectomy with spleen and one patient without spleen.
Postoperative pancreatic endocrine function was examined in 7 patients with islet transplantation. It was disturbed gradually in 5 patients and unchanged in 2 as compared with their preoperative function. In 2 patients with segmental pancreas autograft, one lost pancreatic autograft due to splenic venous thrombosis, and another is alive with normal pancreatic function after operation. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 元島幸一: 肝胆膵. 12. 89-95 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 土屋涼一: Medical Technicology. 13. 89 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 土屋涼一: 胆と膵. 7. 387-391 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 松尾繁年: "消化器外科セミナー25膵癌の診断と治療-最近の進歩-" へるす出版, 15 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 土屋涼一: "膵切除" 医学図書出版, (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ryoichi Tsuchiya: "Pancreatic Islet Autotransplantation" Medical Technicology. 13. 89 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koichi Motojima: "Total pancreatectomy and islet autotransplantation for pancreatic cancer" Kan. Tan. Sui. 12. 95 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ryoichi Tsuchiya: Treatment of pancreatic pseudocyst associated with chronic pancreatitis The Biliary and Pancras. 7. 387-391 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shigetoshi Matsuo: Herusu. How to treat Carcinoma of the pancreas from the view points of its recurrence (Diagnosis and treatment of pancreatic cancer), 15 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ryoichi Tsuchiya: Igakutosho. Pancreatic islet autotransplantation (Pancreatectomy), in press (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 土屋凉一: 胆と膵. 4. 387-391 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 松尾繁年,角田司,原田昇,土屋凉一: "消化器外科セミナー,25;289〜304(再発形式からみた膵癌治療のあり方)" へるす出版, 5 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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