| Project/Area Number |
60480312
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Asahikawa Medical college |
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Principal Investigator |
NAKAJIMA Susumu First Department of Surgery, Asahikawa Medical college, 医学部, 講師 (70091577)
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| Co-Investigator(Kenkyū-buntansha) |
大島 宏之 旭川医科大学, 第一外科学講座, 助手 (90152115)
MAEDA Tomio First Department of Surgery,Asahikawa Medical College, 第一外科学講座, 助手 (50142815)
OHSHIMA Kouji First Department of Surgery, Asahikawa Medical College
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | Porphyrin derivatives / Tumor tissue accumulation / Ga-67 citrate / New tumor positive scintigraphy / Bacterio-pheophorbide |
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| Research Abstract |
Since 1978,our group has examined porphyrin derivatives based on hemoglobin and chlorophyl and their metal complexes(160 in all) and tested their relationships between side chain structure and tumor tissue accumulation. Based on this research,our group started developing new tumor-positive chemicals for scintigraphic use that would improve the diagnosis and treatment of lung cancers.
Recently developed In-111-mono-DTPA-Ethyleneglycol Ga deuterporphyrin(In-111-MDEGD) were applied to Syrian golden hamsters with implanted pancreatic gland cancers,C57-black mice with Lewis lung cancer and nude mice with human lung adenocarcinoma to enable tumor imaging and biodistribution examination.
In the resutant data, In-111-MDEGD showed larger tumor/lung,tumor/kidney and tumor/ blood ratio than with Ga-67-citrate. The affinity of In-111-MDEGD in inflammatory tissue was much lower than that of Ga-67-citrate.
Recently we also found new photosensitizer-(bacterio-pheophorbide)which has maximum absorbance wavelength at 755nm.
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