| Project/Area Number |
60480316
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
OKAMOTO YOSHIFUMI Department of Cardiovascular Surgery associate Professor, 医学部, 助教授 (80116392)
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| Co-Investigator(Kenkyū-buntansha) |
IKADA YOSHIHITO Research Center for Medical Polymers and Biomaterials Professor, 材料, 教授 (00025909)
MATSUMOTO MASAHIKO , 医学部心臓血管外科, 医員
KONISHI YUTAKA , 医学部心臓血管外科, 助手 (70111953)
BAN TOSHIHIKO , 医学部心臓血管外科, 教授 (00173120)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1985: ¥5,300,000 (Direct Cost: ¥5,300,000)
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| Keywords | Small-caliber prosthesis / Polyurethane / Acrylamide / Antithrombotic / SEM / 白血球粘着 |
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| Research Abstract |
Coronary revascularization using the artificial graft is very difficult because of its low patency. The thrombogenic nature of prosthetic material used in vascular reconstructive operations limits the patency of grafts, particularly of small-caliber vascular grafts.
We have demonstrated that polyurethane bound with polyacrylamide, non-ionic water-soluble polymers, did not obsorb protein nor platelets adhere in vitro experiments and did not cause thrombus formation implanted in rat carotid artery.
The aim of the present study was focused on the analysis about thrombo resistance of synthetic polymeric materials and development of a new vascular prosthesis which was able to use for the aortocoronary bypass graftiny. Using mongrel dogs, the prosthesis, polyurethane bound with polyacrylamide were implanted into the carotid, femoral or iliac arteries. A dose of aspirin 40mg/kg, a platelet aggregation inhibitor was administered intravenously before surgery.
The graft patendy was observed in all. The inner surfaces of them were observed optically scaned electromicroscopically.
30 minutes 1 hour and 2 hours after surgery, entire surfaces were covered with deformed white blood cell without platelet adhesion. 22 hours after implantation white blood cells were destructed completely and covered with diffuse thin layer.
From these results, it was concluded that polyurethane coupled with non-ionic water-soluble polyacrylamide might not be complete blood compatible.
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