| Project/Area Number |
60480317
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Osaka University Medical School |
|---|
Principal Investigator |
MATSUDA Hikaru Osaka university Medical School, 1st dept.of Surgery, 医学部, 助手 (00028614)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIRANAKA Toshiyuki Osaka University Medical School, 1st dept.of Surgery, 医学部, 助手 (10173246)
OHTANI Masakatsu Osaka University medical School, 1st dept. of Surgery, 医学部, 助手 (90168980)
|
|---|
| Project Period (FY) |
1985 – 1986
|
| Project Status |
Completed (Fiscal Year 1986)
|
| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥5,900,000 (Direct Cost: ¥5,900,000)
|
|---|
| Keywords | neonat and infant / myocardial protection / crystalloid cardioplegia / mitochondrial score / ミトコンドリアスコア / 細胞内浮種スコア / PG12 analogue / single dose法 / multiple dose法 |
|---|
| Research Abstract |
1. Results of Experimental Studies in 1985
Assessment of the myocardial protectection in infant dogs (n=5) was perfomed under the cardiopulmonary bypass (CPB). 3 of 5 dogs were able to wean off CPB. Mitochondrial score (MtS) and edema score (EdS) of the 3 dogs became worse after reperfusion but there were no difference among them.
2.Results of Experimental Studies in 1986
Comparison of the single-dose (S) administration of cardioplegia (CP) and multiple-dose (M) CP in the isolated new born rabbit hearts were perfomed. The myocardial protection of S was more effective than that of M in terms of % recovery heart rate (%HR), % water content, MtS and EdS.
Comparison of three kinds of crystalloid CP (GIK(S1),GIK with Ca++ and Mg++ (S2) and GIK with Ca++, Mg++ and PGI2 analogue (S3)) were performed in the isolated new born rabbit hearts. The myocardial protection with S3 was more effective than that with S1 and S2 in terms of %HR, % recovery coronary flow, MtS and EdS.
|
