| Project/Area Number |
60480329
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
KENJI Ono Nagasaki University School of Medicine, Assistant Professor, 医学部, 助教授 (60112372)
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| Co-Investigator(Kenkyū-buntansha) |
MAKIO Kaminogo Nagasaki University School of Medicine, Assistant, 医学部, 助手 (40145256)
HIROSHI Baba Nagasaki University School of Medicine, Assistant, 医学部, 助手 (20133176)
KAZUO Mori Nagasaki University School of Medicine, Professor, 医学部, 教授 (50025540)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Partial epilepsy / Cerebral cortex / Basal ganglia / Substantia nigra / Thalamus / Γアミノ酪酸(GABA) |
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| Research Abstract |
The ventral nuclei of the thalamus are involved in the thalamo-caudato-pallidal and thalamo-caudato-nigral loops as well as in the thalamo-cortico-reciprocal circuits. From such a strategic point of view, the ventral nuclei, which have been considered as one of the stereotixic target structurures for relief of intractable zeizure disorder, are very likely to be a crucial structure in the development of partial seizures.
In this study, we developed a chronic model of partial onset generalized seizure induced by low frequency cortical stimulation (LFCS), and examined a possible role of the above structures in the development of LFCS-induced seizures by means of electrophysiological and 2-deoxyglucose autoradiographic approaches. As a result, it was suggested that the convergent inputs from both the cortical focus and the thalamus might play a pivotal role for recruitment of striatal output neurons, thereby inhibiting nigro-thalamic inhibitory projection neurons, and that the subsequent disinhibition of the thalamo-cortical and thalamo-striatal neurons could accelerate to recruit more and more cortical and subcortical neurons. Such a dynamic interaction among the cerebral cortex and subcortical structures suggests, in addition to the other quoted "preferential pathway", a new concept of concurrent involvement of multiple brain structures should be taken into account as a new dimension of our understanding of mechanism involved in partial onset generalized seizure.
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