Measurement of the local blood flow in peripheral nerves

Research Project

Project/Area Number	60480336
Research Category	Grant-in-Aid for General Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Kanazawa University
Principal Investigator	NOMURA Susumu Kanazawa Unicersity,Medical School,Professor, 医学部, 教授 (70019529)
Co-Investigator(Kenkyū-buntansha)	宮崎憲太郎金沢大学, 医学部附属病院, 医員吉水典彰金沢大学, 医学部附属病院, 医員宇賀治行雄金沢大学, 医学部附属病院, 医員 UMEDA Shinichiro Kanazawa University Hospital Lecturer, 医学部附属病院, 講師 (20115215) YOSHIMIZU Noriaki Kanazawa University Hospital Doctor MIYAZAKI Kentaro Kanazawa University Hospital Doctor UGAJI Yukio Kanazawa University Hospital Doctor
Project Period (FY)	1985 – 1987
Project Status	Completed (Fiscal Year 1987)
Budget Amount *help	¥6,000,000 (Direct Cost: ¥6,000,000) Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000) Fiscal Year 1986: ¥2,100,000 (Direct Cost: ¥2,100,000) Fiscal Year 1985: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords	blood flow / electrochemically generated bydrogen / 電解式水素クリアランス法 / 坐骨神経 / 大腿動脈 / 腹腔大動脈 / 血行遮断
Research Abstract	In order to measure the blood flow of tissue we employed the electrochemically generated hvdrogen method. There are,however,some problems in clinically application of this method:one is to determine the diffusion transport value in the absence of blood flow,and the other is the variabliability of the diffusion transport value among the individual eelectrodes. We studied these problems in vivo and in vitro experiments. Significant correlation between the diffusion transport value of tissue without blood flow (y) and that od 0.5% agar gel dissolved in physiological saline at 0゜C(x) was obtained :y=0.80x+0.494. Therefore,it is possible ro determine the diffusion transport value of tissue in vivo from that in vitro. Then,we measured the blood flow of bone marrow by this method experimentally and clinically;in the blood flow of femoral head after fracture-dislocation of the hip. Next,an experimental stuby was performed to clarify the changes in the intraneural microcirculation by the this method. The changes in intraneural blood flow under various stretchings were investigated. Adefinite reduction of blood flow was observed at an clongation of nerve by 7, in intrafuniculus and 5% in subepinural space. Blood flow in intrafuniculus was kept to more than 50% of normal blood flow below 10% elongation of the nerve; on the other hans,in subepineural space it was reduced below 50% at sboout 8% elongation. It was concluded that the influence od iscemia by stretching injury the peripheral nerve was less in initrafunicular blood flow than in subepineural blood flow.