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Studies on the biological effect of underwater shock waves

Research Project

Project/Area Number 60480353
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KAWAHARA Masa-aki  Department of Urology, Tohoku Univ. Sch. Med., 医学部, 助教授 (50006780)

Co-Investigator(Kenkyū-buntansha) METOKI Rikiya  Department of Urology, Tohoku Univ. Sch. Med., 医学部, 助手 (20174328)
KAN Mikio  Research Institute for Tuberculosis and Cancer, Tohoku Univ., 抗酸菌病研究所, 助手 (70125524)
TAKAYAMA Kazuyoshi  Institute of High Speed Mechanics,Tohoku Univ., 高速力学研究所, 教授 (40006193)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1985: ¥4,400,000 (Direct Cost: ¥4,400,000)
KeywordsUnderwater shock wave / Biological effect / Microexplosion / Cultured cancer cell / 腎結石
Research Abstract

The biological effect of underwater shock waves (SW) was studied through following categories : 1) in vitro basical experiments, 2) animal experiments and 3) studies on clinical application of extracorporeal SW lithotripsy. The SW was generated by micro-explosions using chemical explosive pellets of lead azide (10mg), or silver azide (10mg).
1) In vitro experiments: Cavitation bubbles were observed at the focal area, when the SW was focused using ellipsoidal reflecter. And, if the bubble was exposed by another SW, jet-flow generated from the bubble. These two phenomena, caviatation and jet-flow, seemed to associate with the deleterious effect of SW in biological materials. Cultured tumor-cells, when exposed by focused SW, decreased in number, but proliferative ability remained in the 50 times-SW exposure. However, in the case of 100 times-exposure, the ability was lost. The data suggest the possibility of SW-application to cancer therapy. 2) Animal experiments: In the 100-200 times-exposure to the dog kidney, almost no changes occurred including other abdominal organds. However, in the 500 times-SW exposure, bleeding lesions were observed. But after 3 months, no pathological changes were observed except minor scarring lesions. 3) studies on clinical application: Studies on renal function using the uptake rate of 99mTc-DMSA, no statistical change was observed between pre- and post -SW treatment. However, in the cases with stagnated disintegrated fragments in the ureter, which caused hydronephrosis, the renal function decreased markedly. The data suggest that clinical problems in the SW lithotripsy is not the SW itself, but the post-operative hydronephrosis, if exists.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Kuwahara,M.et al.: J.Urol.135. 814-817 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 桑原正明: 医科器械学. 56. 213-217 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 桑原正明: 医用電子と生体工学. 24. 184 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 景山鎮一: 日超医論文集. )13(suppl.I. 837-838 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 黒須清一: 日泌尿会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kuwahara, M. et al.: "Extracorporeal stone disintegration using chemical explosive" pellets as an energy source of underwater shock waves. J. Urol.135. 814-817 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kuwahara, M. et al.: "Extracorporeal lithotripter using microexplosion." Ikakikaigaku. 56. 213-217 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kuwahara, M. et al.: "Extracorporeal microexplosive lithotripsy(EML): Screen-effect of Polyethylenefoam on propagation of underwater shock wave." Jpn. Soc. Med. Elect. and Biol. Engineering. 24. 184 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kageyama, S. et al.: "Extracorporeal microexplosive lithotripsy:Ultrasonic examination before and after the lithotripsy" Jpn. J. Med. Ultrasonics. 13(suppl.). 837-838 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kurosu, S. et al.: "Extracorporeal microexplosive lithtripsy:Effect of underwater shock waves on various organs." Jpn. J. Urol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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