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Adrenal Autotransplantation Technigus and Grafy Survival

Research Project

Project/Area Number 60480356
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionHamamatsu Unicersity School of Medicine

Principal Investigator

USHIYAMA Tomomi (1987)  Depertment of Urology, Hamamatsu Unirversity School of Medicine, 医学部, 助手 (50176658)

牛山 知己 (1987)  浜松医科大学, 医学部, 助手

阿曾 佳郎 (1985-1986)  浜松医大, 医学部, 教授 (00009961)

Co-Investigator(Kenkyū-buntansha) ASO Yoshio  Depertment of Urology, Faeulty of Medicine, Tokyo Univercity., 医学部医学部, 教授 (00009961)
OHTA Nobutaka  Depertment of Urology, Hamamatsu University School of medicine, 医学部, 講師 (50160510)
OHTAEARA Yoshihisa  Depertment of Urology, Hamamatsy University School of Medicine, 医学部, 助手 (80124717)
ATSUSHI Tajima  Depertment of Urology, Hamamatsu University School of Medicine, 医学部, 助教授 (10111808)
牛山 知己  浜松医科大学, 医学部, 助手 (50176658)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsAdrenal / Autotransplantation / Adrerarectomy / 両側性副腎皮質過形成 / 補充療法 / 副腎自家移植 / 両側副腎腺腫 / 原発性副腎皮質過形成 / 副腎皮質の再生 / 3β-hydroxysteroid dehydrogenase
Research Abstract

Autotransplantation of adrenal tissue has been performed clinically,but the resuls is not satisfactory. There are many factoes that may be affect the graft survival:stroid replacement, endogenious or exogenious ACTH,the size and volume of the transplanted tissue the transplanted site and so forth.In order to find the suitable conditions for sutotransplantation,we performed this study
Clinical study:We had experianced 3 adrenal sutotransplantation cases;bilateral adrenal adenoma (casel),primary bilateral nodular hyperplasia(case2),bilateral pheochromocytoms(case3). We realized graft survival in only case 29 In case 1 and case 2,plasma ACTH was low level before operation.In these cases,post operative exogenious ACTH replacement therapy is important for stimulating the regenerations of the graft.And it is necessary for graft survival that the graft contains a part adenoma or hyperplastic tissue In case 3, post operative excessive glucocorticoid replacement therapy suppressed endogenious AC … More TH ans inhibited graft survival
Experimental study: Adult male Wistar rats were used. After bilaterael adrenalectomy,autotransplantation of the unilateral afrenal gland divided to small pieces to the fiank muscle pocket was performed. (1)The process regeneration: On the 7th day after sutgery, regeneration was observed starting from the outer cortical cells sdjacent to the adrenal capsule. On the 56th day, the cortical zonation was found to be restored. (2)The transplanted site:The grafts were transplanted to the flank muscle,thigh muscle,renal capsule or spleen. There were no significant difference in histological and functional restitution9(3)The graft size and volume: One adrenal grand divided to 1/2,1/4, 1/8,1/16 pieces.The graft survival rate of 1/2 piece transplanted group was 60% The grafts of the other group were all survival without histological difference. (4) Steroid and ACTH replacement: Groupl(G1); no replacement, Group2(G2) glucocorticoid replacement. Group3(G3): glucocortcoid plus ACTH replacement. There was no significant difference between levels of ACTH in G1 and G3. Levels of ACTH in G2 were significantly lower those in Gu and G3. The histological study of G1 grafts showed regeneration on the 7th day and gained sull regeneration on the 56th day. In G3, the process of regenerations was similar to G1. The grafts in G2 remained small, disclosed poor regeneration. The results indicate that the steroid replacement alone supresses endogenous ACTH ans inhibits the graft survival. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 阿曽佳郎: 内分泌外科. 2. 155-160 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 阿曽佳郎: 外科治療. 52. 880-883 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 阿曽佳郎: カレントテラピー. 3. 1369-1381 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 牛山知己: 内分泌外科. 4. 175-178 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 阿曽佳郎: 日本内分泌学会誌. 63. 664-668 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 中野優: ホルモンと臨床. 35. 993-998 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 広瀬淳: 日本泌尿科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masaru Nakano: "Cushings syndrome" Clinical Endocinology. 35. 993-998 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Jun Hirose: "Histological and Endocrinological Observations the Regeneration of the Autoteansplanted adrenal Glrena Goand in the Rat." The Japanese Journal of Urology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 牛山知己,田島惇,阿曽佳郎: 内分泌外科. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 広瀬淳,増田宏昭,牛山知己,大田原佳久,太田信隆,鈴木和雄,田島惇,阿曽佳郎: 日本泌尿器科学会雑誌. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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