• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Anti-tumor activity in regional lymph nodes of the patients with bladder cancer

Research Project

Project/Area Number 60480359
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKochi Medical College

Principal Investigator

FUJITA Yukitoshi  Kochi Medical College, Professor, 医学部, 教授 (10033060)

Co-Investigator(Kenkyū-buntansha) WATANABE Hironobu  Kochi Medical College, Asistant, 医学部, 助手 (20201220)
KAMEI Yoshihiro  Kochi Medical College, Lecturer, 医学部, 講師 (40145149)
杉田 治  高知医科大学, 医学部, 助手 (70171155)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1985: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsAnti-tumor activity / Regional lymph nodes / Natural killer activity / T-lymphocyte / NK活性 / モノクローナル抗体 / 抗腫瘍括性
Research Abstract

We investigated natural killer (NK) activity and T-lymphocyte subsets in peripheral blood and regional lymph nodes in order to examine the host's defense mechanisms against cancer. Materials were obtained from 10 patients with bladder cancer and 3 patients with benign diiseases used as control. NK activity was measured by chemiluminescense assay, a new method which is well correlated to the ^<5i>Cr-release assay, and T-lymphoctye subsets were stained with anti-Leu-2,-3, -4,-7, and -11 monoclonal antibody. The NK activity of regional lymph nodes was lower than that of peripheral blood in all 13 cases, and the percentage of Leu 7^+ and Leu 11^+ cells was in agreement with that of the NK activity detected by chemiluminescense assay. In peripheral blood, the percentage of Leu 3^+ cells was reduced in high stage patients as compared to low stage patients and controls but in regional lymph nodes it was paradoxically increased. In cancer tissue the percentage of Leu 3^+ cells was higher than that of Leu 2^+ cells and few Leu 7^+ and 11^+ cells were obserbed. The significance of these results will become clear as more cases are examined.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 山下元幸: 日本癌治療学会誌. 22. 498 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Motoyuki Yamashita: "Analysis of NK cell activity in genitourinary malignant tumors" The Journal of Japan Society for Cancer Therapy. 23. 464- (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi