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The Studies on Spontaneous and Occupational Uroepithelial Cancer : Tissue Polypeptide Antigen as a Marker

Research Project

Project/Area Number 60480362
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionWakayama Medicaj College

Principal Investigator

YASUKAWA Shu (1987)  Wakayama Medical College, (泌尿器科学), 助手 (80191120)

森本 鎮義 (1985-1986)  和歌山県医大, 医学部, 助手 (20094683)

Co-Investigator(Kenkyū-buntansha) AOSHI Hideo  Wakayama Medical College, 泌尿器科学, 助手 (50191846)
YOSHIDA Toshihiko  Wakayama Medical College, 泌尿器科学, 助手 (00174938)
深谷 俊郎  和歌山県立医科大学, 泌尿器科学, 助手 (10183584)
YOSHIDA Masanori  Wakayama Medical College, 泌尿器科学, 助手 (90182782)
MORIMOTO Shigeyoshi  Wakayama Medical College, 泌尿器科学, 講師 (20094683)
UEKADO Yasunari  Wakayama Medical College
安川 修  和歌山県立医科大学, 医学部, 助手 (80191120)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1986: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsurinary tissue polypeptide antigen / Tween 40 / bladder cancer / 職業性膀胱腫瘍 / フィルター / 界面活性剤
Research Abstract

Aiming to decrease the false-positive of urnary TPA in patints with urinary tract infection, this reseach was started. At first we tried to do the treatment of uirine samples with a filter in order to remove fragments of debris. the results indicated, however, that urinary TPA had a tendency to absorp to a filter and form aggregates. Furthermore these absorption and aggregation of urinary TPA disappeared by the pre-treatment of urine samples with Tween 40 , one of the surface active agents. Then, the basic studies on the measurements of urinary TPA with Tween 40 treatment were done. Although by the Tween 40 trearment the TPA values were elevated in almost all urine samples, the justification of its treatment was confirmed from the rersults in recovery test and dilution test.
The usefulness of urinary TPA as a tumor marker in bladde cancer was indicated from the results that the positive rates were 72.7% in spot urine and 75.0% in 24-hours urine of bledder cancer patients. On the contrary, among the benign urological diseases studied the patients groups with cyctitis and urolithiasis revealed respectable false-positve rates of urinary TPA even if treated with Tween 40. In the study on chemical worhers, who had been previously exposed to benzidine or <beta>-naphthilamine, the positive rate was two times more than healthy controls.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report

Research Products

(6 results)

All Other

All Publications (6 results)

  • [Publications] 森本鎮義: 日本泌尿器科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉田全範: 泌尿器科紀要.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 藤永卓治: 日本災害医学会会誌. 33. 453-457 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shigeyoshi Morimoto et al.: "Improvement in the determination of urinary tissue polypeptide antigen. ( TPA ) and the clinical study in bladder cancer patients" The Japanese Jounnal of Urology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masanori Yoshida et al.: "Clinacal studies on urinary tissue polypeptide antigen ( TPA ) : Problem and improvement in determination" Acta Urologica Japonica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takuji Fijinaga et al.: "Tissue polypeptide antigen ( TPA ) in the screening examination for occupational urothelial cancer" Japanese Journal of Traumatology and Occupational Medicine. 33. 453-457 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-03-30   Modified: 2016-04-21  

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