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Integrated Studies on Endocrino-Metabolic Mechanisms of Fetal Growth and Fetal Distress

Research Project

Project/Area Number 60480368
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKobe University School of Medicine

Principal Investigator

MOCHIZUKI Matsuto  Kobe University School of Medicine, Professor, 医学部, 教授 (80030922)

Co-Investigator(Kenkyū-buntansha) UEDA Yasuo  Kobe University School of Medicine, Research Assoc, 医学部, 助手 (20168636)
DEGUCHI Masaki  Kobe University School of Medicine Hospital, Research Assoc, 医学部附属病院, 助手 (70163938)
MARUO Takeshi  Kobe University School of Medicine, Assist, Professor, 医学部附属病院, 講師 (60135811)
MORIKAWA Hajime  Kobe University School of Medicine, Assist. Professor, 医学部, 講師 (30030894)
ASHITAKA Yoshihiko  Kobe University School of Medicine, Assoc. Professor, 医学部, 助教授 (10030959)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥5,200,000 (Direct Cost: ¥5,200,000)
KeywordsFetal Growth / Fetal Distress / Pregnancy Induced Yhpertension / Metabolism During Pregnancy / Calcium / 甲状腺ホルモン
Research Abstract

The purpose of this study is to determine the mechanisms operating in cases of intrauterine growth retardation (IUGR) and fetal distress. Maternal endocrine, metabolic, and physiologic profiles were investrigated and the results are summarized as follows: (1) Maternal glucose metabolism and fetal growth: (a)Using an in-vivo setup, strepto- zotocine-induced hyperglycemia in rats resulted to growth-retarded offsprings; also; the induction of glucagon receptors in rat fetuses' liver was impaired; (b)In an invitro study using fetal rat liver cultures, insulin-like growth factor-l showed a growth-promoting effect by fecilitating glycogen synthesis and cell proliferation in the rat fetuses. (2) Pregnancy-induced hypertension (PIH): (a) In patients with PIH, salt loading test led to a remarkable rise in blood pressure. Angiotensin II loading test failed to suppress secretion of renin and bradykinin. In situ, the vasodepressor system could be stimulated but its reserve function against angiote … More nsin II may stili be less than in mormal pregnancy; (b) Intracellular Na^+ concentration in severe PIH was significantly increased with an associated rise in intracellular Ca^<++> level. Such increase in Ca^<++> level results to myometrial contraction of blood vessels. (3) Calcium metabolism: Serum levels of Ca^<++> and P in PIH were significantly lower than in mormal pregnancy. However, serum PTH was elevated. These changes could be attributed to a reduction in Ca and P absorption from the intestines because of an associated low serum levels of the active form of Vit.D3.Using rat intestine, hPL activated Vit.D3 enhanced Ca^<++> absorption. (4) Thyroid hormone: Higher reverse T3 and lower free T3 levels were observed in PIH patients' sera. These could be the result of intensified maternal hypometabolism where T4 to rT3 conversion is more dominant than T4 to T3 conversion. However, placental inner monodeiodination seems to prevent active movement of thyroid hormone from mother to the fetus. (5) Fetal growth and fetal distress: This study proves that in cases of PIH, fetal growth retardation induced by a state of placental insufficiency significantly contributes to the development of chronic fetal distress. Ultrasonographic antepartum assessment of fetal growth might be effective and appropriate in predicting fetal distress in cases of high risk pregnancy. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 出口正喜: 日本新生児学会雑誌. 22. 362-271 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小原範之: 日本内分泌学会誌. 62. 784-796 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 中山洋: 日本産科婦人科学会雑誌. 38. 1578-1586 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 丸尾原義: 日本新生児学会雑誌. 23. 492-500 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 藤井良造: 日本内分泌学会雑誌. 63. 1241-1254 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三村治: 日本内分泌学会雑誌. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masaki,Deguchi: "A New Marker for Prediction of Fetal Distress" Acta Neonatologica Japonica. 22. 362-371 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Noriyuki,Ohara: "Calcium Metabolism and Calcium-regulating Hormones during Normal Pregnancy" Folia Endocrinologica Japonica. 62. 1578-1586 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Motoyoshi,Maruo: "Studies on the Dynamics of Thyroid Function in Early Neonatal Period" Acta Neonatologica Japonica. 23. 492-500 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ryozo,Fujii: "Studies on the Dynamics of Insulin Secretion and the Regulatory Mechanism of Insulin Receptor in fetal Rats" Folia Endocrinologica Japonica. 63. 1241-1254 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroshi,Nakayama: "Studies on the Relationships between Reproductive Phenomenon and Thyroid Function" Acta Obstetrica et Gynaecologica Japonica. 38. 1578-1586 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 出口正喜: 日本新生児学会誌. 22. 362-371 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 小原範之: 日本内分泌学会誌. 62. 784-796 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 小原範之: 日本内分泌学会誌. 62. 882-896 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Sulchan Sofoewan: Kobe Journal of Medical Sciences. 32. 115-125 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 丸尾原義: 日本新生児学会誌. 23. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 藤井良造: 日本内分泌学会誌.

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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