| Project/Area Number |
60480398
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
TAKAMORI KENSHIRO School of Dentistry, Showa University, 歯学部, 教授 (80013853)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI TAKESHI School of Dentistry, Showa University, 歯学部, 助手 (10159585)
YAMAMOTO AYAKO School of Dentistry, Showa University, 歯学部, 助教授 (20085773)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | Bacteroides intermedius / Fibrous capsule / Amorphous capsule / Antiphagocytic factor IgK / <C_3> / 多糖体 |
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| Research Abstract |
Oral Bacteroides intermedius possess capsules of two type were examined for their capability of resistant to phagocytosis by PMN. Fibrous capsulated strains had been high resistant to phagocytosis. In contrast, its of amorphous were readily phagocytosed. Bacterial cells of fibrous capsulated strain grown in broth possessed large amont of visoosus polysaccharide ( PS ). This PS was found to consist of galactose and mannose in the rate of 1 : 7. and had capability of high resistant when determined by sensitivity to phagocytosis of PS coated particle or IgG or <C_3> conjugated beads in the presence of PS. The results indicated that the PS from fibrous capsule of Bacteroides intermedius is involved in resistant to phagocytosis and inhibit uptake induced by IgG or <C_3> .
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