| Project/Area Number |
60480434
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
外科・放射線系歯学
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| Research Institution | Osaka University , Faculty of Dentistry |
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Principal Investigator |
SAKUDA Masayoshi 2nd Dep. Maxillofacial Surgery, Professor, 歯学部, 教授 (00028755)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZAWA Mitsuhiro 2nd Dep.Maxillofacial Surgery, Resident, 歯学部附属病院, 医員 (70217701)
TAKITA Masaaki 2nd Dep.Maxillofacial Surgery, Asistant, 歯学部, 助手 (30188122)
YONEDA Toshiyuki 2nd Dep.Maxillofacial Surgery, Asistant, 歯学部, 助手 (80142313)
SUGAWARA Toshio 2nd Dep.Maxillofacial Surgery, Asistant professor, 歯学部, 講師 (10116048)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1985: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Tumor immunity / NK activity / CTL / CTL |
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| Research Abstract |
In this studies, the relationship between NK activity and cytotoxic T lymphocytes (CTL) were examined in splenic lymphocytes of tumor bearing mice.
Furthermore, mechanisms on the rise and fall of NK activity and CTL were investigated after inoculation of cryo-destructed tumor cells.On the bases of these results, the usefulness of cryosurgery was discussed from a standpoint of tumor immunotherapy.
[ Results ] NKcells belong, at least in part, to the T cell lineage, and the NK cells might be converted to CTL, in the tumor bearing mice. This possible pathway is considered to be due to control with sialic acid of cell surface.
Cryo-destructed tumor cells enhanced NK activity, and could not induced CTL. On the contrary, tumor cells treated with MMC induced low NK activity,and could induce CTL. It was suggested that these rise and fall of NK activity and CTL related to interferon, prostaglandin E , suppressor T cells or interleukin 2.
Thus cryosurgery augmented the non-specific immunity such as NK activity,but could not induce tumor-specific immunity.
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