Photoresponsive and Blood-Compatible Elastomers Composed of poly (oxyeteramethylene) Units
| Project/Area Number |
60550640
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子合成
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KOHJIYA Shinzo (1986-1987) Kyoto Institute of Technology. Associate Professor, 工芸学部, 助教授 (50027900)
〓谷 信三 (1987) 京都工芸繊維大学, 工芸学部, 助教授
こうじ谷 信三 (1985) 京都工芸繊維大学, 工芸学部, 助教授
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| Project Period (FY) |
1985 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Elastomer / Poly(oxytetramethylene) / Polyurethane / Photoresponsive / Photochromism / Potomecanical / Antithrombogenic / エラストマー / 機能性エラストマー / ポリオキテトラメチレン / ビオローゲン / ポリウレタンウレア |
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| Research Abstract |
Two functionalized polymers, i.e., photoresponsive and blood-compatible elastomers were synthesized by means of living cationic polymerization of tetrahydrofuran(THF) or by use of hydroxy-terminated poly(oxytetramethylene). In the polymerization of THF, the conditions governing the molecular weight were established, and it was a success to introduce dimethylamino groups to the ends of the polymer. The polymer was subjected to the reaction with dihalides to produce ionene-type elastomers. The elastomers were found to be amphiphilic both in their solution viscosities and their gas permeabilities. Viologen-type elastomers were successfully prepared, which were found both photochromic and photomecanical, i.e., irradiation of light changed the color and also affeced to the mechanical properties.
New polyurethaneurea containing both oxyetramethylene and oxyethylene units was prepared, whose blood copatibilities were investigated; in vitro and in vivo antithrombogenicity tests and the complement system activation. In these three evaluations, the polyurethaneurea displayed very good results. In addition, the mechanical properties of this polymer were excellent in tensile, stress-relaxation, and dynamic mechanical tests. The polyurethaneurea was found to be a very promising biomedical material for artificial organs, for examples, artificial hearts and blood vessels.
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Report
(2 results)
Research Products
(18 results)
