| Project/Area Number |
60570064
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Wakayama Medical College |
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Principal Investigator |
TAMAI Yasuhiko Wakayama Medical College, 医学部, 助教授 (00073677)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1985: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Oculomotor cortex / Monocular eye movement / Motor cortex / Eye movement / Presylvian sulcus / Anterior ectosylvian sulcus / Coronal sulcus / Cat |
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| Research Abstract |
One of the major organizational principles of primate and feline eye movements is binocular parallel movements. However, I previously reported that stimulation of the fundus of the coronal sulcus (COR) evoked monocular movement of the contralateral eye in the cat. The descending pathway of the monocular eye movement system and its corticocortical connections to other cortices responsible for eye movements were studied in cats using microelectrode and horseradish peroxidase (HRP) tracing methods.
Antidromic spike of cortical neuron in the COR was evoked ipsilaterally following stimulation of the mesencephalic reticular formation (MRF). Retrogradely labeled cell bodies were found in the same ipsilateral cortex in the COR following injection of HRP solution on the MRF where the antidromic spike was evoked. Orthodromically labeled neural terminals were found in the ipsilateral MRF adjacent to the deep layer of the superior colliculus, the superficial layer of the superior colliculus and pontine nuclei following HRP injection in the fundus of the COR.
Corticocortical connections of the frontal oculomotor areas (FOAs) such as the medial wall of the hemisphere under the cruciate sulcus (CRU), the fundus of the presylvian sulcus (PRE) and the COR were as follows: the medial wall of the hemisphere under the CRU received fibers from the medial bank of the PRE. The fundus of the COR received fibers from the lateral bank of the PRE. The FOAs received fibers from the ipsilateral ventral bank of the anterior ectosylvian sulcus (AES) corresponding to the anterior ectosylvian visual area (AEV). Following HRP injection into the ventral bank of the AES, labeled cell bodies were detected in the cortex of the caudal end of the suprasylvian sulcus (caudal end of the Clare-Bishop area). These findings suggest that the monocular eye movement system gets information from the AEV, as well as other FOAs, and send fibers directly to the MRF to drive the contralateral eye.
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