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Chronobiological approach to total parenteral nutrition.

Research Project

Project/Area Number 60570132
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionEhime University

Principal Investigator

SAITO Masayuki  Ehime University, (Associate Professor), 医学部, 助教授 (80036441)

Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
KeywordsParenteral nutrition / 生体リズム / 栄養投与パターン
Research Abstract

To clarify the effects of nutrient administration pattern on circadian rhythms, body temperature, urine volume and blood hormone levels were measured at 4-hour intervals for 24 hours in patients receiving total enteral nutrition (TEN) with a liquid diet. The patients were divided into two groups, and the diet was continuously given through a day in continuous TEN group, whereas from 8 a.m. to 8 p.m. in cyclic TEN group.
In cyclic TEN group, all circadian rhythms examined were nearly normal: that is, body temperature was low in the morning and high in the evening, urinary excretion was less in the morning, and plasma cortisol level was highest in the early morning and lowest in the evening. In contrast, in continuous TEN nutrition, there was no significant circadian rhythmic change in all parameters except urinary excretion. The urine volume showed a normal rhythm regardless of the pattern of nutrient infusion.
It was concluded that the pattern of nutrient intake is important for generation and maintenance of normal circadian rhythms and that cyclic TEN is more adequate, at least from a chronobiological standpoint, than continuous TEN, especially when patients were kept under TEN for a long period.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 斉藤昌之: 栄養日本. 28. 35-42 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 西村浩治: 外科と代謝・栄養. 20. 164-171 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hideo Kato: J.Clin.Biochem.Nutr.2. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Masayuki Saito: "Circadian Clocks and Zeitgebers" Hokkaido Univ.Press, 190(10) (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 斉藤昌之: "新小児医学大系,3B,小児栄養学" 中山書店, 286(20) (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] M. Saito: "Biological rhythms and nutrition." Eiyo-Nippon. 28. 35-42 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] K. Nishimura et al.: "Effects of total enteral nutrition on the circadian rhythm." Jap. J. Surg. Metab. Nutrition. 20. 164-171 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] H. Kato: "Effects of cyclic and continuous total enteral nutrition on circadian cortisol rhythm." J. Clin. Biochem. Nutr.2. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] M. Saito: Hokkaido Univ. Press. Circadian Clocks and Zeitgebers, 146-156 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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