• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Histiocytic proliferative lesions of the soft tissues

Research Project

Project/Area Number 60570149
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionFukouka University

Principal Investigator

IWASAKI Hiroshi  Fukuoka University Associate Professor, 医学部, 助教授 (90101170)

Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordssoft tissue / histiocyte / fibroblast / myofibroblast / macrophage / monocyte / reticuloendothelial system / 悪性線維性組織球腫 / モノクローナル抗体 / 細胞膜抗原 / 細胞培養
Research Abstract

Using whole cell antigens prepared from the established lines of human malignant fibrous histiocytoma(MFH),we have generated four different monoclonal antibodies (FU3,FU4,FU5,FU6) by a mouse hybridoma technique.By indirect immunoperoxidase in frozen tissue sections,FU3 and FU4 revealed strong staining of perivascular mesenchymal cells and fibroblasts.Macrophages in granulation tissues as well as monocytes and other blood cells in normal peripheral blood were uniformly negative for the antigen detected by FU3.Immunoelectron microscopic studies demonstrated positive reactions with FU3 and FU4 on the surface of MFH cell membrane,suggesting that these antibodies recognized cell surface antigens.MFH shares antigenicity with perivascular mesenchymal cell and fibroblast.MFH may have a common origin from the perivascular mesenchymal cells that are supposed to have a potential for multidirectional differentiation.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Iwasaki,H.: American Journal of Pathology. 128. 528-537 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 諌山照刀: 福岡大学医学紀要. 14. 191-203 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iwasaki,H.: Pathol.Res.Pract.182. 248-254 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iwasaki H,Isayama T,Johzaki H, Kikuchi M: "Malignant fibrous histiocytoma evidence of perivascular mesenchymal cell origin. iMmunocytochemical studies with monoclonal anti-MFH antibodies." Am J Pathol. 128. 528-537 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Iwasaki H, Isayama T, Ichiki T, Kikuchi M: "Intermediate filaments of myofibroblasts:immunochemical and immunocytochemical analyses." Pathol Res Pract. 182. 248-254 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 城崎洋,岩崎宏,諌山照刀,菊池昌弘: 医学のあゆみ. 139. 213-214 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 石井龍,岩崎宏,菊池昌弘: 医学のあゆみ. 139. 419-420 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Iwasaki,H;Isayama,T;Ichiki,T;Kikuchi,M: Pathol Res Pract.

    • Related Report
      1986 Annual Research Report
  • [Publications] Iwasaki,H;Isayama,T;Johzaki,H;Kikuchi,M: Am J Pathol.

    • Related Report
      1986 Annual Research Report

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi