| Project/Area Number |
60570175
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
寄生虫学(含医用動物学）
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUJITA Koichiro Nagasaki University School of Medicine, 医学部, 教授 (90053107)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIDATE Setsuko Nagasaki University School of Medicine, 医学部, 助手 (40121256)
HORII Yoichiro Nagasaki University School of Medicine, 医学部, 助手 (80173623)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Filaria / Strongyloides / ATL / Helper T / IL-2 |
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| Research Abstract |
The birth places of pacients with adult T-cell leukemia (ATL) are clustered in the rural coastal areas in Kyushu and South Shikoku. Among several endemic diseases, the geographical distribution of patients with bancroftian filariasis is most similar to that of ATL in Japan. In the survey of Goto Islands of Nagasaki Prefecture, we formulated an etiological hypothesis that a combination of repeated exposure to filaria infection and ATL virus (ATLV) might have played an important role in the etiology of ATL. In the study of Kikai-Island, Kagoshima Prefecture where ATL is endemic and patients with filariasis had been commonly observed until 1975, similar results coud be observed. on the other hand, it was shown in Okinawa-Islands that the patients with strongyloides had higher rate of ATLV than non-infected persons, and same results were obtained in Kikai-Island, endemic area of strongyloides infection. These results suggested that filarial infection in the past as well as strongyloides infection in the present might have some promoting effects on ATLV infection and/or ATLV proliferation.
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