Studies on the membrane complement inhibitors by use of reconstituted liposome membrane
| Project/Area Number |
60570231
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Fukuoka University |
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Principal Investigator |
OKADA Noriko Fukuoka Univ., Sch. Med., 医学部, 助手 (20160682)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1985: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | alternative complement pathway / liposome / membrane glycoprotein / species specificity / 補体抑制 |
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| Research Abstract |
Glycoproteins from erythrocyte membrane were incorporated into the artificially reconstituted liposome membranes and their effect on the alternative complement pathway was analysed. The results obteined are as follows;
1) Glycoprotein(GP) from guinea pig erythrocytes inhibits the alternative pathway of guinea pig complement.
2) For the inhibition, the glycoprotein was required to be present on the same membrane where complement activation occured.
3) The membrane glycoprotein has been shown to inhibit the amplification reaction of the alternative complement pathway.
4) The inhibitory capacity of the glycoprotein on the liposome membrane was aborished by proteinase-K treatment.
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Report
(1 results)
Research Products
(10 results)
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[Publications] Koga, T. Kakaimoto, K., Hirofuji, T., Kotani, S., Ohkuni, H., Watanabe, K., Okada, N., Okada, H. , Sumiyoshi, A. and Saisho, K.: "Acute joint inflammation in mice after systemic injection of the cell wall, its peptidoglycan and chemically defined peptidoglycan subunits from various bacteria" In fection and Immunity. 50. 27-34 (1985)
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