Studies on the successive effects of noise exposure to pregnant mice

Research Project

Project/Area Number	60570237
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Mie University
Principal Investigator	SAKAMOTO Hiroshi Dep. of Hygiene, Mie University School of Medicine, Professor, 医学部, 教授 (40024674)
Co-Investigator(Kenkyū-buntansha)	MURATA Mariko Dep. of Hygiene, Mie University School of Medicine, Assistant, 医学部, 助手 (10171141) TAKIGAWA Hiroshi Dep. of Hygiene, Mie University School of Medicine, Ass.Professor, 医学部, 助教授 (80126979) YAMAMURA Hideki Dep. of Anatomy, Mie University School of Medicine, Professor, 医学部, 教授 (40034003)
Project Period (FY)	1985 – 1986
Project Status	Completed (Fiscal Year 1986)
Budget Amount *help	¥1,500,000 (Direct Cost: ¥1,500,000) Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000) Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords	Noise effect / Teratogenicity / Cadmium / Trypan blue / 動物実験
Research Abstract	The purpose of this study is to clarify the noise effects on the fetus development. Since the other influencing factors besides noise could not control in epidemiological survey subjected human. the animal experiment was performed. This study was composed of two parts. One was the observation on the effects of noise exposure only. Another was the observation on the mode of modification by noise exposure on teratogenicity due to cadmium and trypan blue administration. Pregnant ICR mice were exposed to wide octave band noise at 100 dB(A) in three ways; "N" :exposed continuously for six hours only on day 7 of pregnancy, "DN" :exposed intermittently (ON-time 15 minutes, OFF-time 15 minutes)for six hours only on day 7 of pregnancy, "LN" :exposed continuously for six hours everyday from day 7 to 12 of pregnancy. Simple effect of noise was different between the three ways of noise exposure.The growth of fetuses was inhibited significantly by the exposure of "DN" condition. The incidence of external malformed fetuses increased significantly under the condition of "N" and "DN" exposure. On the other hand, noise exposure did not modify the incidence of abnormal fetuses by cadmium administration. But, in trypan blue administration, the incidence of abnormal fetuses was suppressed by noise exposure under the condition of high dose administration, although it was not suppressed,occasionally accelerated, by noise exposure under the condition of low dose administration.