| Project/Area Number |
60570247
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Tokyo Women's Medical College |
|---|
Principal Investigator |
JUN KAGAWA Tokyo Women's Medical College;Professor, 医学部, 教授 (90055955)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATORU SHIMIZU Tokyo Women's Medical College; Instructor, 医学部, 助手 (70158963)
|
|---|
| Project Period (FY) |
1985 – 1987
|
| Project Status |
Completed (Fiscal Year 1987)
|
| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
|
|---|
| Keywords | Nitrogen dioxide / Nitrogrnoxides / Bronchial reactivity / Bronchial sensitivity / Histamine |
|---|
| Research Abstract |
In order to investigate the effect of repeated exposure to 0.5 ppm NO_2 on bronchial response to histamine challenge, 24 male Hartley guinea pigs were exposed to 0.5 ppm NO_2 or filteres air for 5 hr/days, 5days/week, for 11 weeks. Evary 10 days, boy weight, total respiratory flow resistance and bronchial reacivity to histamine aerosol were determined. In NO_2 group, a tendency of dectrase of body weight was observed. The effective concentration of histamine that produced a 100% increase of baseline total respiratory flow resistance before histamine challenge (PC_<100>) in NO_2 group was lower than that of filters air group during the first several weeks of exposure. However. these differences between NO_2 and filtered air groups were small and not statistically significant.
|
