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Effects of exposures to various air pollutants on experimental asthma induction, in particular on its late asthmatic response.

Research Project

Project/Area Number 60570253
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionMie University

Principal Investigator

YOSHIDA Katsumi  Mie University Medical School, Professor, 医学部, 教授 (20024664)

Co-Investigator(Kenkyū-buntansha) KITABATAKE Masayoshi  Mie University Medical School, Lecturer, 医学部, 講師 (00024688)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsNitrogen Dioxide / Airway Sensitization / Breathing Curve / Late Asthmatic Response / Air Pollution / 気管支喘息
Research Abstract

On bronchial asthma, it is pointed out that late asthmatic response (LAR) is important and its significance is large, but its adequate identification/experimental procedure has not been developped for the difficulty of objective long-time observation (over 48 hours) on experimental animals' breathing symptoms.
In the first step of our project, new procedure of long-time exact observation on breathing symptoms was planned to be developped. Animals (guinea pigs) were fixed in bodyplethsmo-boxes, and each output was amplified, converted to digital data, and stored in hard-disk. Stored data were analized numerically to obtain the following indices of respiratory frequency, ecpiration/ inspiration-ratio (expiratory/inspiratory elongation), breathing curve pattern, power spectrum of breathing curve etc.
With this system, effect of nitrogen dioxide on LAR was investigated. By ovo-albumin or candidaextract spray, it was noticed that LAR was elevated siginificantly by exposure to nitrogen dioxide (0.5 ppm X 24 hours X 4 days).

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 吉田克巳: 三重大学環境科学研究紀要. 10. 119-124 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 吉田克巳: アレルギー. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] K. Yoshida, M. Kitabatake, N. Uchida et al: "Numerical Analysis with Personal Computer on Breathing Curves obtained from experimentally asthma-induced Guinea Pigs" Report of Environmental Science of Mie University. 10. 119-124 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] K. Yoshida, M. Kitabatake and N. Uchida: "Identification and Recording of experimental Asthma LAR with personal Computer" Allergy.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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