| Project/Area Number |
60570304
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHIMIZU Shiro Kanazawa Medical University, Dept. of Int. Med., 医学部・血液免疫内科, 講師 (50097432)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Makoto Kanazawa Medical University, Dept. of Int. Med., 医学部・血液免疫内科, 助手 (50170824)
IMAOKA Teiji Kanazawa Medical Universitd, Dept. of Int. Med., 医学部・血液免疫内科, 講師 (80106814)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Autoimmune disease / Interleukin 2 / インターロイキン2リセプター / 全身性エリテマトーデス / シェーグレン症候群 |
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| Research Abstract |
Interleuki 2 (IL-2) production and interlenkin 2 receptor (IL-2R) expression in T and B lymphocytes obtained from patients with autoimmune diseases, systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS), were studied.
1)T-lymphocytes obtained from patients with SLE or SS produced IL-2 significantly less then normal control T lymphocytes.
2)IL-2R expression in T lymphocytes obtained from patients with SLE or SS was also significantly less than IL-2R expression in normal T lymphocytes.
3)IL-2R expression in suppressor/killer subset of T lymphocytes was much less than that in helper/inducer subset of patients with autoimmune diseases.
4)IL-2R expression in patient's T-lymphocytes was normalized when IL-2 was added to the lymphocyte culture. Furthermore, suppressor T cell functions were also normalized after adding IL-2 to the culture.
5)IL-2R expression in B-lymphocytes and B lymphoblastoid cell lines derived from patients with autoimmune diseases or abult T-cell leukemia was observed by using cytofluorography and electron-microscopy combined with gold-immunostaining These results suggest that decreased IL-2 production by T-lymphocytes play the primary role in abnormal IL-2R expression in T-lymphocytes obtained from patients with autoimmune diseases.
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